DeCure's autonomous AMR AI scientist is researching a drug-repurposing hypothesis for Vibrio infectious disease — screening already-approved drugs against its 5-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleVibrio infectious disease maps to a 5-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for vibrio infectious disease is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
matrix metallopeptidase 7 (MMP7) — MMP7 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet 2sdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 2Y6D · 1.6 Å · ligand N-[(2S)-1-[4-(5-BROMOPYRIDIN-2-YL)PIPERAZIN-1-YL]SULFONYL-5-PYRIMIDIN-2-YL-PENTAN-2-YL]-N-HYDROXY-METHANAMIDE (TQJ). Experimental structure, not a prediction.
What the evidence adds up to
A 2023 study showed that a toxin delivery system found in various vibrios mediates lethality in an aquatic animal. The same system had previously been reported to induce inflammasome-mediated cell death in mammalian phagocytic cells. The authors suggest this delivery system and its associated toxins may contribute to the emergence of pathogenic strains.
A 2020 review of Vibrio vulnificus infections in Korea noted that the disease was first reported there in 1979 as a necrotizing skin disease of unknown cause, causing panic due to dreadful wounds and high mortality. Although the nature of the disease is now better understood and public fear has dissipated, a certain number of infected patients still occur each year and the high mortality rate remains a major health and social problem.
A 2020 study on Vibrio cholerae found that L-arabinose induces the formation of viable, nonproliferating spheroplasts that can revert to proliferating rods when L-arabinose is removed. A 2021 review noted that vibrio population dynamics are usually affected by climate and seasonal factors, and that over recent years the incidence of diseases caused by vibrio infection has increased significantly due to rising seawater temperature and climate change. The review stated that vibrio pathogenicity is related to virulence factors encoded by virulence genes, and that the process of infecting a host is determined by multiple virulence factors acting together, not by a single factor.
A 2017 in silico analysis described docking studies of haemolysin protein in Vibrio parahaemolyticus, but provided no clinical or survival data. What is still missing is any clinical trial testing a specific drug against vibrio infection in humans, any patient stratification based on virulence factors or host response, and funding for translational work that moves beyond in silico models and aquatic animal lethality assays.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Microbiology Spectrum · 2023 · 16 citations · open access
A <i>Vibrio</i> T6SS-Mediated Lethality in an Aquatic Animal Model
Abstractand the human illnesses associated with them. Since vibrios often share virulence traits horizontally, a better understanding of their virulence potential and determinants can prepare us for new emerging pathogens. In this work, we showed that a toxin delivery system found in various vibrios mediates lethality in an aquatic animal. Taken together with previous reports showing that the same system induces inflammasome-mediated cell death in mammalian phagocytic cells, our findings suggest that this delivery system and its associated toxins may contribute to the emergence of pathogenic strains.
Infection and Chemotherapy · 2020 · 15 citations · open access
Historical and Clinical Perspective of<i>Vibrio vulnificus</i>Infections in Korea
AbstractVibrio vulnificus infection was first reported as a necrotizing skin disease of unknown cause in Korea in 1979. In the early days, this disease caused panic across the country due to dreadful wound and its high mortality. Since then, the nature of the disease has become better understood and the overwhelming public fear has dissipated. However, there are still a certain number of infected patients each year and the high mortality rate remains a major health and social problem. From this review on historical and clinical perspective, better understanding of V. vulnificus infection would provide valuable information for public health planning.
Applied and Environmental Microbiology · 2020 · 10 citations · open access
<scp>l</scp> -Arabinose Induces the Formation of Viable Nonproliferating Spheroplasts in Vibrio cholerae
Abstractto form viable reversible spheroplasts. Indeed, the quick transition to spheroplasts and reversion to proliferating rods by addition or removal of L-Ara is ideal to understand the genetic program governing this physiological state and the spatial rearrangements of the cellular machineries during cell shape transitions.
IntechOpen eBooks · 2021 · 2 citations · open access
Community Change and Pathogenicity of<i>Vibrio</i>
AbstractVibrio is a rod-shaped Gram-negative bacteria, which is widely distributed in marine and estuarine environments worldwide. It is an important component of the aquatic ecosystem and plays an important role in biogeochemical cycle. Its population dynamics are usually affected by climate and seasonal factors. Most of the Vibrios in the environment are not pathogenic, but some of them are pathogenic bacteria for human and animal, such as Vibrio cholerae, Vibrio vulnificus, Vibrio parahaemolyticus, and Vibrio anguillarum, etc., which are generally reported to be related to aquatic animal diseases and human food-borne diseases. Over the last couple of years, due to the influence of the rising seawater temperature and climate change, the incidence of diseases caused by Vibrio infection has increased significantly, which poses a great threat to human health and aquaculture. The research on pathogenic Vibrio has attracted more and more attention. The abundance and community changes of Vibrio in the environment are usually controlled by many biological and abiotic factors. The Vibrio pathogenicity is related to the virulence factors encoded by virulence genes. The process of Vibrio infecting the host and causing host disease is determined by multiple virulence factors acting together, instead of being determined by a single virulence factor. In this chapter, community changes of Vibrio, as well as the virulence factors of Vibrio and the related virulence genes of Vibiro are summarized, and their important roles in Vibrio infection are also discussed.
In Silico Analysis on Docking Studies of Haemolysin Protein in Vibrio Paraheamolyticus
AbstractIntroduction Vibriosis is a disease caused by vibrio belongs to genus Vibriobacteria. It is a Gram-negative bacterium, possessing a curved-rod shape, Vibriosis is mainly causative disease for marine organism like shrimps, fishes etc.other than marine organism it will cause disease to humans by f
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
