DeCure's autonomous Cardio AI scientist is researching a drug-repurposing hypothesis for vascular disease — screening already-approved drugs against its 37-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleVascular disease maps to a 37-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for vascular disease is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
lipoprotein(a) (LPA) — LPA is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
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RCSB Protein Data Bank · entry 8TCE · 1.07 Å · ligand (2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic acid (HWF). Experimental structure, not a prediction.
What the evidence adds up to
The 1995 review describes how genetic models of human vascular disease were historically obtained through serendipity and selective breeding, yielding models of atherosclerosis and hypertension. It notes that molecular techniques such as transgenics, homologous recombination, and in vivo gene transfer later allowed precise alteration of animal genotypes to study phenotype changes, leading to breakthroughs in understanding pathogenesis and treatment. No specific drug, survival data, or response rates are reported.
The 2015 review discusses posttranscriptional gene regulation in the vascular endothelium under hypoxia, focusing on noncoding RNAs such as microRNAs, antisense transcripts, and RNA-binding proteins. It states that functional integration between the microRNA pathway and the cellular hypoxic response, along with dynamic interactions between RNA-binding proteins, microRNAs, and antisense RNAs, reveals a critical layer of control for gene expression. The authors claim these findings have diagnostic and therapeutic implications for vascular disease, but no clinical outcomes, sample sizes, or drug effects are provided.
The 1961 German textbook on angiology describes the anatomy, physiology, pathophysiology, and pathology of peripheral circulatory disturbances, classifying vascular disorders as neuropathic or organic lesions affecting arterial, venous, and lymphatic circulation. It notes angiology was then a subspecialty of only ten years. No treatment efficacy data or drug names are given.
The 1940 literature review states that the study of vascular diseases is difficult and open to criticism, that instrumentation is largely unnecessary for diagnosis, and that arteriosclerosis had received too little attention. It reports three monographs on peripheral vascular disease were published that year. No drug, survival, or response data appear.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Circulation · 1995 · 28 citations
Genetic Models of Human Vascular Disease
AbstractThe use of genetic models has greatly assisted investigations of the natural history, mechanisms, and potential therapy for human vascular disease. In the past, genetic models of vascular disease were obtained through serendipity and/or selective breeding to obtain inbred lines that express the phenotype of interest. This approach has yielded several valuable models of atherosclerosis and hypertension. In the past several years, the advent of molecular techniques has enabled investigators to produce additional novel genetic models of disease that have further enhanced the study of vascular biology and medicine. Transgenic techniques and the techniques of homologous recombination have allowed researchers to alter the genotype of an animal in a precise manner and to study the resultant change in phenotype. More recently, techniques of in vivo gene transfer have also accelerated and enhanced the development of novel models. The application of these methodologies has resulted in important breakthroughs in our understanding of the pathogenesis and treatment of vascular diseases. In this review, we compare and contrast these technologies along with examples of their use in the studies of vascular biology and medicine.
Current Opinion in Hematology · 2015 · 1 citations
Posttranscriptional adaptations of the vascular endothelium to hypoxia
AbstractPURPOSE OF REVIEW: Remarkable new advances have been made in the field of posttranscriptional gene regulation over recent years. These include the revelation of noncoding RNAs, such as microRNAs, antisense transcripts and their interactions with RNA-binding proteins (RBPs) in the context of both health and disease settings, such as hypoxia. In particular, these discoveries bear much relevance to the field of vascular biology, which historically has focused upon transcriptional processes. Thus, the contributions of these posttranscriptional gene regulatory mechanisms to vascular and endothelial biology represent a newer concept that warrants discussion. RECENT FINDINGS: Recent studies have revealed two emerging themes that are critical to endothelial/vascular biology and function. First is the functional integration between the microRNA pathway and the cellular hypoxic response, which, in addition to specific microRNAs, involves key components of the microRNA biogenesis machinery. A key concept here is the regulation of a master transcriptional programme through posttranscriptional mechanisms. The second major theme involves the dynamic interactions between RBPs, microRNAs and antisense RNAs. The condition-dependent collaborations and competitions between these different classes of posttranscriptional regulators reveal a critical layer of control for gene expression. SUMMARY: Taken together, these findings bear significant diagnostic and therapeutic implications for vascular disease.
Archives of Internal Medicine · 1961 · 0 citations
Angiologie: Pathologie, Klinik und Therapie der peripheren Durchblutungsstörungen
AbstractThis reference book on angiology was written by prominent German clinicians and edited by Ratschow, who for many years specialized in this field. The anatomy of the arteries and capillaries is described first. Presentation of the physiology and pathophysiology of the peripheral blood circulation follows. Pathological anatomy of the arterial system is described next. The etiology and pathogenesis of peripheral circulatory disturbances is the topic of the following chapter. General diagnostic aspects and general therapy are discussed in separate chapters. The second part of the book contains the description of the different vascular diseases. Vascular disorders are classified as neuropathic and organic lesions. The latter include abnormalities of the arterial, venous, and lymphatic circulation. The final chapter is devoted to the aspects of life insurance as related to peripheral vascular disease. Angiology is a recent subspecialty of cardiovascular diseases with a history of only 10 years. New diagnostic methods and
Archives of Internal Medicine · 1940 · 0 citations
VASCULAR DISEASES
AbstractREVIEW OF SOME OF THE RECENT LITERATURE BY DR. VAN DELLEN AND DR. SCUPHAM In these reviews of the past six years we have not attempted to include all of the available literature on vascular diseases. Many deserving articles have undoubtedly been missed, and consequently the reviews must not be considered complete. Preference was usually given to articles containing original ideas, as well as to those confirming or disproving existing beliefs. Many articles were included on merit alone, or their contents were thought worthy of repetition. The study of vascular diseases is not without its difficulties and is open to criticism. The vast amount of instrumentation is certainly unnecessary for diagnosis; in the majority of cases the history and findings alone are sufficient. Arteriosclerosis, the most prevalent vascular disease, has received too little attention. Three monographs dealing with diseases of the peripheral vessels were published during the past year. Of
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
