DeCure's autonomous Nephrology AI scientist is researching a drug-repurposing hypothesis for urinary tract obstruction — screening already-approved drugs against its 20-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleUrinary tract obstruction maps to a 20-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for urinary tract obstruction is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2) — PAPSS2 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet bgcdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 7FH3 · 1.8 Å · ligand beta-D-glucopyranose (BGC). Experimental structure, not a prediction.
What the evidence adds up to
In 169 female patients with outlet obstruction studied urodynamically, treatment outcomes were analysed for 102 patients. Patients with stable detrusors and those with recurrent urinary tract infection responded well to treatment provided the obstruction was adequately relieved. Symptomatic relief was less common in patients with unstable detrusors, even when outflow readjustment was adequate.
In 32 patients with equivocal upper urinary tract obstruction, pressure flow studies and renography were compared. The renogram failed to confirm the presence or absence of obstruction in 39 per cent of cases as shown by the pressure flow study. Both methods have advantages, disadvantages and technical pitfalls.
Urge incontinence in women is multifactorial and in most patients the underlying cause remains unclear. Symptomatic treatment with detrusor inhibiting drugs is the mainstay of therapy for idiopathic cases. Many drugs have been proposed but documentary proof of their efficacy varies. Limited efficacy and systemic side effects are frequent problems with available drugs. A 2019 review of pharmacotherapy for urinary disorders notes that with research into newer drugs with better efficacy and fewer side effects, treatment is becoming more specific and efficacious, but gives no concrete numbers for any drug in obstruction.
No drug is named in these abstracts as a treatment for urinary tract obstruction. What is missing is any controlled trial of a specific pharmacological agent for obstruction itself, as opposed to urge incontinence or infection, and any data on patient stratification beyond detrusor stability and infection history.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
British Journal of Urology · 1975 · 146 citations
A Urodynamic View of Bladder Outflow Obstruction in the Female: Factors influencing the Results of Treatment
Abstract169 female patients with outlet obstruction have been studied urodynamically. The results of treatment of the outlet obstruction in 102 patients have been analysed and the reason for the failures discussed. Patients with stable detrusors and those with symptoms of recurrent urinary tract infection responded well to treatment, provided this relieved the obstruction adequately; symptomatic relief was less common in patients with unstable detrusors, despite adequate outflow readjustment.
A Comparison of Pressure Flow Studies and Renography in Equivocal Upper Urinary Tract Obstruction
AbstractThe ability of pressure flow studies and renography to assess obstruction was compared in 32 patients with equivocal upper urinary tract obstruction. The renogram failed to confirm the presence or absence of obstruction in 39 per cent of the cases as shown by the pressure flow study. Both studies have advantages, disadvantages and technical pitfalls.
AbstractUrge incontinence is a common symptom in women. The etiology is multifactorial. In most patients, however, the underlying cause remains unclear. Symptomatic treatment with detrusor inhibiting drugs constitutes the mainstay of therapy in these idiopathic cases. Many drugs have been proposed although the documentary proof of their efficacy varies. Limited efficacy and systemic side effects are frequent problems using available drugs. Rational pharmacotherapy requires an up to date knowledge of the physiology, pathophysiology and the clinical pharmacology of the lower urinary tract. The principles of drug therapy should be based on: 1) meticulous assessment of the patient; 2) precise classification of the bladder dysfunction; 3) individual drug selection and dose adjustment; and 4) current control with critical assessment of the indications for continued therapy.
International Journal of Innovative Research in Medical Science · 2019 · 0 citations · open access
A Review of Pharmacotherapy in the Treatment of Urinary Disorders
AbstractUrinary tract infections and other related pathophysiological conditions are a plethora of ailments affecting mankind. Ailments that are as common as the urinary tract infection, uropathy, incontinence, calculi and many other disorders. With the advancement of research into newer and more potent drugs with better efficacy and lesser side effects, treatment is becoming more specific and efficacious. This review examines the recent development in the treatment of these disorders and impressive progress in the pharmacotherapy, it also gives an overview of current and future prospects of drugs for bladder disorders.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
