DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for spindle cell lipoma — screening already-approved drugs against its 3-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleSpindle cell lipoma maps to a 3-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for spindle cell lipoma is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
What the evidence adds up to
Spindle cell lipoma is a benign tumour of mature fat tissue that occurs chiefly in middle-aged to elderly males, most often in the shoulder, posterior neck, and back. A 1979 case reported the first orbital occurrence in a 42-year-old woman; a 2018 arm case and a 2016 dorsal foot case were also described. A 2019 case from the buccal mucosa of a 45-year-old woman was added. Treatment is excision, and no recurrence is reported.
The 2019 article on an atypical lipomatous tumour/well-differentiated liposarcoma (ALT/WDL) in a 69-year-old woman’s gluteal region is a direct warning: the tumour histologically, immunohistochemically (CD34 positive, RB1 loss), and molecularly mimicked spindle cell lipoma, yet harboured MDM2 and CDK4 amplification, supporting classification as ALT/WDL. The authors state that in atypical clinical contexts, molecular studies for MDM2/CDK4 should be considered in tumours resembling spindle cell lipoma, because the oncogenesis and clinical behaviour of ALT/WDL and spindle cell lipoma are markedly different.
No drug treatment is mentioned in any of these abstracts. The literature consists entirely of case reports and a single diagnostic cautionary case. There is no trial, no cohort, no survival data, and no response rate to report. The missing elements are any study of systemic therapy, any prospective series, any patient stratification by molecular subtype, and any funding for such work.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Archives of Ophthalmology · 1979 · 39 citations
Spindle Cell Lipoma of the Orbit
AbstractA 42-year-old woman had an orbital mass lesion removed surgically that proved histologically to be a spindle cell lipoma. To our knowledge, this is the first reported case of a spindle cell lipoma arising in the orbit. This specific type of lipoma occurs chiefly in male patients and is believed to affect the shoulder and posterior neck regions almost exclusively. Spindle cell lipomas, while having unusual features histologically, are benign and should not be mistaken for liposarcomas or other spindle cell soft-tissue tumors.
International Journal of Surgical Pathology · 2019 · 15 citations
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma With Features Mimicking Spindle Cell Lipoma
AbstractAtypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and spindle cell lipoma are lipomatous tumors with distinct clinical, molecular, and prognostic features. Although histological and immunophenotypic features can overlap between ALT/WDL and spindle cell lipoma, the oncogenesis and clinical behavior are markedly different. In borderline cases, molecular analysis for MDM2 or CDK4 amplification can aid in distinguishing ALT/WDL from spindle cell lipoma. Although dedifferentiated liposarcoma has been reported to harbor both MDM2 amplification and loss of the RB1 region, we are not aware of a reported RB1 loss in well-differentiated ALT/WDL. In this article, we present a 69-year-old woman with a lipomatous tumor in the gluteal region that histologically, immunohistochemically, and molecularly mimicked spindle cell lipoma (with positive immunohistochemical staining for CD34 and loss of the RB1 gene region), yet harbored amplification of MDM2 and CDK4 confirmed by fluorescence in situ hybridization, supporting classification as ALT/WDL. This case strengthens the argument that in atypical clinical contexts, molecular studies for MDM2/CDK4 should be considered in tumors resembling spindle cell lipoma.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · 2018 · 0 citations · open access
Spindle Cell Lipoma of the Arm: A Case Report with Review of Literature
AbstractSpindle cell lipomas are rare benign tumours of adipocytes. They are usually found in middle aged to elderly males. There are a number of differential diagnoses for this lesion. Treatment is excision with no recurrence. Here we report a case of a firm non tender swelling of the arm which after excision was diagnosed as Spindle Cell Lipoma (SCL). We discuss the case and a review of the literature for a deeper understanding of this tumour.
Turkish Journal of Plastic Surgery / Türk Plastik Rekonstrüktif ve Estetik Cerrahi Dergisi · 2016 · 0 citations
Spindle Cell Lipoma of the Dorsal Parts of the Foot
AbstractSpindle cell lipoma (SCL) is a tumor of the mature fat tissue that the collagen producing spindle cells take place in varying proportions. Most frequently, it settles on the back and neck and is located in the subcutaneous tissue. It is commonly seen in male patients in the 4th–5th decades. In addition to immunohistochemical examination, histopathological examination is necessary for the differential diagnosis. In this study, a spindle cell lipoma located on the dorsal foot was discussed along with the current literature review.
Cumhuriyet Dental Journal · 2019 · 0 citations · open access
Spindle Cell Lipoma of the Buccal Mucosa- A Case Report
AbstractSpindle cell lipomas are a distinct variant of lipomas that occur very rarely in the oral cavity. The most common site for occurrence of this entity in the oral cavity is the tongue. The presence of spindle cells in the lesion calls for critical histopathological evaluation of the lesion. Here we present a new case of spindle cell lipoma that occurred on the buccal mucosa of a 45-year-old female patient. We provide an insight to the pathogenesis and the pathology of the entity.
Polish Journal of Pathology · 2014 · 0 citations · open access
Letter to the Editor<br>Re: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley
AbstractENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Laliotis A, Bree E, Vasilaki S, Papadakis M, Melissas J. Letter to the EditorRe: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley. Polish Journal of Pathology. 2014;65(3):250-252. doi:10.5114/pjp.2014.45791. APA Laliotis, A., Bree, E., Vasilaki, S., Papadakis, M., & Melissas, J. (2014). Letter to the EditorRe: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley. Polish Journal of Pathology, 65(3), 250-252. https://doi.org/10.5114/pjp.2014.45791 Chicago Laliotis, Aggelos, Eelco De Bree, Stavrianthi Vasilaki, Michael Papadakis, and John Melissas. 2014. "Letter to the EditorRe: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley". Polish Journal of Pathology 65 (3): 250-252. doi:10.5114/pjp.2014.45791. Harvard Laliotis, A., Bree, E., Vasilaki, S., Papadakis, M., and Melissas, J. (2014). Letter to the EditorRe: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley. Polish Journal of Pathology, 65(3), pp.250-252. https://doi.org/10.5114/pjp.2014.45791 MLA Laliotis, Aggelos et al. "Letter to the EditorRe: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley." Polish Journal of Pathology, vol. 65, no. 3, 2014, pp. 250-252. doi:10.5114/pjp.2014.45791. Vancouver Laliotis A, Bree E, Vasilaki S, Papadakis M, Melissas J. Letter to the EditorRe: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley. Polish Journal of Pathology. 2014;65(3):250-252. doi:10.5114/pjp.2014.45791.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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