DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for situs inversus — screening already-approved drugs against its 3-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleSitus inversus maps to a 3-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for situs inversus is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
bromodomain and WD repeat domain containing 1 (BRWD1) — BRWD1 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 3Q2E · 1.74 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
A 2012 case report describes a 59-year-old African woman with gallstones and situs inversus totalis who underwent a single-port cholecystectomy using a single trocar access device. The procedure was uneventful, and the authors concluded that this approach may be an option for such surgery even in patients with situs inversus totalis. No other patients were reported, and no comparative data exist.
A 2014 case report describes a 57-year-old man with hepatocellular carcinoma who received a liver transplant from a 73-year-old woman with situs inversus totalis, a donor considered marginal. The liver was implanted using a piggyback technique, positioning the larger hemiliver in the left upper quadrant. The graft reperfused well without surgical or anaesthetic problems. The patient was discharged on postoperative day 7 and was alive and in good clinical condition at 8 months follow-up. The authors state this is the first reported use of the 1992-Belghiti piggyback technique with a situs inversus totalis donor graft and argue that donor situs inversus totalis should not be considered a contraindication for liver transplantation.
A 2017 case report on anaesthetic management of a patient with situs inversus totalis and dextrocardia posted for oro-faciomaxillary surgery notes the estimated prevalence of situs inversus totalis as 1 in 10,000 births. The report emphasises potential difficulties during anaesthetic management but provides no patient outcomes or numerical data beyond the prevalence figure.
All three reports are single cases, so no controlled comparisons, response rates, or survival statistics are available. What is missing is any systematic trial, any patient stratification by underlying genetic cause or associated ciliary dysfunction, and any funding for prospective studies of surgical or anaesthetic approaches in this rare condition.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Journal of Medical Case Reports · 2012 · 12 citations · open access
Single-port cholecystectomy in a patient with situs inversus totalis presenting with cholelithiasis: a case report
AbstractINTRODUCTION: Situs inversus totalis (mirror image organs) is a rare condition and may affect the intra-abdominal viscera as well as the intrathoracic organs. Cholelithiasis is not more common in these conditions, but the diagnosis may be more difficult. CASE PRESENTATION: We present the case of a 59-year-old African woman with gallstones and situs inversus totalis. A single-port cholecystectomy was performed using a single trocar access device (SITRACC). CONCLUSIONS: The procedure was uneventful, showing that this approach may be an option for this kind of surgery even in patients with situs inversus totalis.
International Journal of Surgery Case Reports · 2014 · 6 citations · open access
Side-to-side caval anastomosis in a patient receiving a liver graft from a marginal donor with situs inversus totalis
AbstractINTRODUCTION: The donor situs inversus totalis status was considered an absolute contraindication to liver transplantation due to the technical difficulties involved. Only in recent years has a very young deceased donor with situs inversus totalis been considered as a potential donor. PRESENTATION OF CASE: We herein report a single case of 57-year-old male patient with hepatocellular carcinoma who received a liver transplantation from a 73-year-old woman with situs inversus totalis. Liver was implanted using a 1992-Belghiti piggyback technique positioning the larger hemiliver in the left upper quadrant and the left in the liver fossa. We assisted a good graft reperfusion without surgical or anesthetic problems. His hospital stay was relatively uneventful and he was discharged from hospital on postoperative day 7. At 8 months of follow-up the patient is alive and in good clinical condition. DISCUSSION: The donor situs inversus totalis does not require any modification of transplant procedure if the donor-recipient size match permits a comfortable placement of the graft in a standard anatomical position. To the best of our knowledge, this is the first case of liver transplantation with a graft from a "marginal" donor with situs inversus totalis using a 1992-Belghiti piggyback technique. CONCLUSION: The donor situs inversus totalis status should not be considered a contraindication for LT and the piggyback technique should be considered the surgery of choice.
ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter · 2017 · 0 citations
Anaesthetic Management of a Patient with Situs Inversus and Dextrocardia Posted for Oro-Faciomaxillary Surgery
AbstractSitus inversus totalis is a rare syndrome, with an estimated prevalence of 1/10,000 births, characterized by the inverted position of the thoracic and abdominal organs with respect to the sagittal plane. In a patient with situs inversus totalis the anaesthetic management during the respective surgical procedure is challenging. The present case report lays an emphasis on the potential difficulties during anaesthetic management and its various implications.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
