DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for prolapse of female genital organ — screening already-approved drugs against its 23-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleProlapse of female genital organ maps to a 23-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for prolapse of female genital organ is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
T-box transcription factor 5 (TBX5) — TBX5 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet 2-{2-[2-(2-ethoxy-ethoxydrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 2X6U · 1.9 Å · ligand 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL (PE4). Experimental structure, not a prediction.
What the evidence adds up to
A 2014 study of bacterial colonisation in genital prolapse reported that the condition is common, with an incidence of 56.3% in women aged 50 and older, and that women under 45 constitute 30–37.5% of patients, while those under 30 account for 10.1–12.3%. The same paper noted that severe forms involving adjacent organs have become more prevalent in recent years. A 2021 review stated that pelvic organ prolapse is present on examination in 40–60% of parous women and, while not life-threatening, causes significant morbidity and reduced quality of life.
A 2018 study of 159 patients who underwent vaginal surgery compared autoplasty of the anterior and posterior vaginal walls added to traditional operations against traditional operations alone. The 79 patients who received the autoplasty technique had a reduction in treatment time of 2.7 days, and the authors reported increased effectiveness of surgical treatment based on clinical indicators. No specific response rates, recurrence rates, or long-term follow-up data were provided.
Another 2018 paper described the use of Corelax vaginal cones for prophylaxis of genital prolapse in the late postpartum period, but gave no numerical results, sample sizes, or comparative outcomes. The abstract only stated that the method was studied and that the article illuminated the research data.
No drug treatment for genital prolapse is mentioned in any of these abstracts. All interventions discussed are surgical or mechanical (vaginal cones). What remains missing is any randomised controlled trial comparing these techniques against sham or no treatment, any data on patient-reported quality of life or sexual function outcomes, and any stratification by prolapse stage or connective tissue phenotype. Funding for such trials, rather than further descriptive studies, is what is absent.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
DOAJ (DOAJ: Directory of Open Access Journals) · 2014 · 2 citations · open access
Bacterial colonization of female reproductive tract in genital prolapse (preliminary results)
AbstractFor many years, prolapse of internal reproductive organs in women has been quite a common gynecological disease [1, 2, 4, 11-13] often requiring surgical correction. The incidence of genital prolapse (56.3%) is highest at the age of 50 and above, however recently the disease has tended to become younger. Women under 45 years constitute 30-37.5% of genital prolapse patients, women under 30 years old - 10.1-12.3%. Severe forms of the disease have prevailed over the recent years, involving adjacent organs and deterioration of their function [4].
HEALTH OF WOMAN · 2018 · 1 citations · open access
Prophylaxis of genital prolapse in women in the late postpartum period
AbstractThe article describes genital prolapse as a pathology of female genital organs. The factors leading to the occurrence of genital prolapse in women of different age groups are presented. Clinical manifestations and mechanisms of their occurrence are substantiated. Considered variants of treatment of women with genital prolapse of various degrees of severity. Illumination of the data of our research of the method of prophylaxis of genital prolapse in the late postpartum period with the help of Corelax vaginal cones. Key words: genital prolapse, rectocele, pelvic floor, connective tissue, vaginal cones.
Zenodo (CERN European Organization for Nuclear Research) · 2018 · 0 citations · open access
Autoplasty of the anterior and posterior walls of the vagina when the prolapse of female genital organs
AbstractA comparative analysis of the results of treatment of 159 patients with prolapse and prolapse of the female genital organs. All patients were operated on with vaginal access. Taking into account the age of the main and concomitant gynaecological and extragenital pathology, an individual program of preoperative preparation, surgical treatment and postoperative management was prepared for each patient. 79 patients underwent autoplasty of the anterior and posterior walls of the vagina, complementing the traditional operations. Evaluation of the results of treatment was carried out according to clinical indicators. The use of this technique has reduced the treatment time by 2.7 days, increased the effectiveness of surgical treatment of patients with prolapse and prolapse of the female genital organs.
Cambridge University Press eBooks · 2021 · 0 citations
Urogenital Prolapse
AbstractUrogenital prolapse is the descent of the pelvic organs into the vagina. It is often seen in conjunction with bowel, bladder and/or sexual dysfunction symptoms, and although usually not life-threatening, can cause significant morbidity and decrease in quality of life. Pelvic organ prolapse is common and is present on examination in 40–60% of parous women [1].
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
