Rare & Orphan Lab · DeCure for X
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Peutz-Jeghers syndrome — screening already-approved drugs against its 2-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
No approved-drug candidate for peutz-jeghers syndrome is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
serine/threonine kinase 11 (STK11) — STK11 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
RCSB Protein Data Bank · entry 8VSU · 2.86 Å · ligand ADENOSINE-5'-DIPHOSPHATE (ADP). Experimental structure, not a prediction.
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
AbstractJournal Article A case of peutz-jeghers syndrome Get access R Kumar R Kumar Surgical Registrar Alder Hey Children's Hospital, Liverpool Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 50, Issue 220, September 1962, Pages 230–231, https://doi.org/10.1002/bjs.18005022023 Published: 06 December 2005
https://doi.org/10.1002/bjs.18005022023AbstractPeutz-jeghers syndrome is a rare inherited disorder with autosomal dominant transmission that manifests primarily as peri-orificial cutaneous-mucous lentiginosis and gastrointestinal hamartomatous polyps with the possibility of other locations in the lungs and reproductive organs. The main complications are gastrointestinal bleeding, bowel obstruction and rectal prolapse. This disease is associated with a high risk of malignant degeneration not only digestive but also pulmonary, mammary, testicular hence the need for a regular long-term codified monitoring. The treatment is most often conservative especially in children in growth period.
https://doi.org/10.15406/ghoa.2021.12.00465Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
