DeCure for Pelger-Huet-like anomaly and episodic fever with abdominal pain
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Pelger-Huet-like anomaly and episodic fever with abdominal pain — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease modulePelger-Huet-like anomaly and episodic fever with abdominal pain maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for pelger-huet-like anomaly and episodic fever with abdominal pain is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
CCAAT enhancer binding protein epsilon (CEBPE) — CEBPE is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet tcedrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 3T92 · 1.5 Å · ligand 3,3',3''-phosphanetriyltripropanoic acid (TCE). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Internal Medicine · 2012 · 5 citations · open access
An Atypical Familial Mediterranean Fever Patient Who Developed Ulcers in the Terminal Ileum and Recurrent Abscess-like Lesions in Multiple Organs
AbstractWe herein describe the case of a 25-year-old woman who suffered from atypical familial Mediterranean fever for more than a decade. She presented with a periodic fever, abdominal pain and persistent ulcers in the terminal ileum. Colchicine was effective, and familial Mediterranean fever was diagnosed. A genetic study showed a heterozygous E148Q mutation in the MEFV gene. Multiple, recurrent, abscess-like lesions developed asynchronously in the spleen, liver, and a lung. Infliximab was administered when colchicine treatment became ineffective. However, infliximab treatment soon became ineffective, probably because antibodies were generated against it. Therefore, etanercept treatment was started, and the patient showed an immediate response.
Archives of Pediatrics and Adolescent Medicine · 1937 · 1 citations
ACUTE APPENDICITIS IN THE EXANTHEMS
AbstractAbdominal pain and vomiting are frequent symptoms of the onset of the exanthems. The attention of the observer is at first focused on the abdomen but is diverted when the exanthematous nature of the illness becomes apparent. Fortunately, the early abdominal symptoms of these diseases usually subside without local sequelae. Abdominal pain may recur, or it may set in for the first time during the period of eruption or shortly afterward. Like the prodromal pain, the pain with the onset of the rash is regarded lightly, because usually no serious complication occurs. It is our purpose to emphasize that there are exceptional cases in which prompt surgical intervention is required. In the presence of one of the exanthems, such as scarlet fever, the evaluation of abdominal symptoms becomes more difficult, but delay in the recognition of an emergency requiring surgical intervention may be avoided if the possibility of such an
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
