DeCure.ai

Rare & Orphan Lab · DeCure for X

DeCure for Osteosclerosis

DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for osteosclerosis — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.

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The disease map

Disease moduleOsteosclerosis maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.

Research record

01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash

Current lead

No approved-drug candidate for osteosclerosis is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.

What the evidence adds up to

Since Albers-Schönberg first wrote about congenital osteosclerosis (marble bone) in 1904, roughly 30 cases had been reported by 1935, mostly from Germany. The author notes that most diagnoses were made by accident while looking for other conditions, and suggests the condition is probably not as rare as believed. No treatment or outcome data are given in that 1935 report.

A 1957 review lists the known causes of diffuse osteosclerosis: hypothyroidism, postoperative hyperparathyroidism, neoplasia (especially carcinoma of the prostate), hypervitaminosis D and more rarely A, fluorosis, and phosphorus poisoning. Primary disorders of unknown aetiology causing increased bone density include Paget's disease. The author states that pathogenesis is poorly understood and that clinical and x-ray features do not usually suggest the aetiology. No treatment or survival data are provided.

A 2014 case report describes intramedullary osteosclerosis, an uncommon benign condition of endosteal new bone formation in long tubular bones of the lower extremity. The authors state that treatment and aetiology are unknown, and that there are no specific clinical findings except leg pain. The case was mistaken for radiculopathy from lumbar disease. No drug therapy, response rates, or survival figures are given.

What is still missing: prospective studies that distinguish between the many causes of osteosclerosis, any controlled trial of a treatment, and patient stratification by aetiology or genetic subtype. No drug has been tested in any of these reports.

Evidence

Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.

Annals of Internal Medicine · 1935 · 4 citations

CONGENITAL OSTEOSCLEROSIS (MARBLE BONE)

AbstractArticle1 February 1935CONGENITAL OSTEOSCLEROSIS (MARBLE BONE)CARROLL M. POUNDERS, M.D., F.A.C.P.CARROLL M. POUNDERS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-8-966 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Albers-Schönberg1first wrote about this rare and interesting condition in 1904, descriptions of it with reports of approximately 30 cases have appeared in the literature. The majority of them originated in Germany with a few from America, Switzerland, France and Italy. Since most of the diagnoses have been made by accident while looking for other conditions, it is probable that it is not so rare as has been believed. Liévre2reminds us that it is not likely that the condition would in reality be so largely limited to the German speaking countries and suggests that the diagnosis has doubtless...References1. ALBERS-SCHÖNBERG HE: Röntgenbilder einer seltenen Knochenerkrankung, München. med. Wchnschr., 1904, li, 365. Google Scholar2. LIÉVRE JA: Les os de marbre, Bull. méd., Paris, 1929, xliii, 1231-1234. Google Scholar3. PÉHUPOLICARDDUFOURT MAA: L'ostéopétrose ou maladie des os marmoréens, Presse méd., 1931, xxxix, 999-1003. Google Scholar4. KUDRJAWTZEWA N: Über Marmorknochenkrankheit, Arch. f. klin. Chir., 1930, clix, 658-687. Google Scholar5. KARSHNER RG: Osteopetrosis, Am. Jr. Roentgenol., 1926, xvi, 405-419. Google Scholar6. STEPHENSBREDECK DJJF: Aleukemic myelosis with osteosclerosis, ANN. INT. MED., 1933, vi, 1087-1096. Google Scholar7. PIRIE AH: Development of marble bones, Am. Jr. Roentgenol., 1930, xxiv, 147-153. Google Scholar8. CLAIRMONTSCHINZ PHR: Case of Albers-Schönberg's marble bones, Arch. f. klin. Chir., 1924, cxxxii, 347-380. (Abstr., Jr. Am. Med. Assoc., 1925, lxxxiv, 405.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma*Received for publication July 27, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlbers-Schonberg diseaseKrankheiten der Knochen, Gelenke und MuskelnOsteopetrosis 1 February 1935Volume 8, Issue 8Page: 966-971KeywordsBone ePublished: 1 December 2008 Issue Published: 1 February 1935 PDF downloadLoading ...

https://doi.org/10.7326/0003-4819-8-8-966
Annals of Internal Medicine · 1957 · 1 citations

GENERALIZED OSTEOSCLEROSIS ASSOCIATED WITH DIABETES INSIPIDUS AND NEUROLOGIC SYMPTOMS

AbstractCase Reports1 March 1957GENERALIZED OSTEOSCLEROSIS ASSOCIATED WITH DIABETES INSIPIDUS AND NEUROLOGIC SYMPTOMSD. W. JOHNSTON, M.D.D. W. JOHNSTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-3-619 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONDiffuse osteosclerosis is of varied etiology. Its pathogenesis is poorly understood. The clinical and x-ray features have become stereotyped in most cases, but do not as a rule suggest the etiology.The conditions in which osteosclerosis, with or without hyperostosis, is seen, are:1. Hypothyroidism.2. Postoperative hyperparathyroidism.3. Neoplasia, especially carcinoma of the prostate.4. Hypervitaminosis D and, more rarely, A.5. Fluorosis.6. Phosphorus poisoning.The known causes of overgrowth of periosteal bone are:1. Syphilis.2. Healed scurvy.3. Healed rickets.The primary disorders of unknown etiology which cause increased density of bone are:1. Paget's...Bibliography1. HingeMenck-Thygesen JP: A case of generalized osteosclerosis, Am. J. Roentgenol. 66: 595, 1951. Google Scholar2. Mellanby E: Skeletal changes affecting the nervous system produced in young dogs by diets deficient in vitamin A, J. Physiol. 99: 467, 1941. CrossrefMedlineGoogle Scholar3. Brailsford JE: Radiology of joints and bones, 4th Ed., 1948, The Williams & Wilkins Co., Baltimore, p. 552. Google Scholar4. McPeak CN: Osteopetrosis, Am. J. Roentgenol. 36: 816, 1936. Google Scholar5. Fairbank T: Atlas of general affections of the skeleton, 1951, The Williams & Wilkins Co., Baltimore, p. 33. Google Scholar6. JacksonAlbrightDrewryHanelinRuben WPFGJMI: Metaphyseal dysplasia, epiphyseal dysplasia, diaphyseal dysplasia and related conditions. I. Familial metaphyseal dysplasia and craniometaphyseal dysplasia, Arch. Int. Med. 94: 871, 1954. CrossrefGoogle Scholar7. Wilkie J: Fluorine osteosclerosis, Brit. J. Radiol. 13: 213-217, 1940. CrossrefGoogle Scholar8. WeinmanSicher JPH: Bone and bones, 1947, C. V. Mosby Co., St. Louis, p. 277. Google Scholar9. FranklinMatheson ELI: Melorheostosis, Brit. J. Radiol. 15: 185, 1942. CrossrefGoogle Scholar10. Kibby SV: Melorheostosis, Radiology 37: 62, 1941. CrossrefGoogle Scholar11. Joseph SW: Clinical Conference at Brooke Army Hospital, Fort Sam Houston, Texas, J. Pediat. 46: 233, 1955. MedlineGoogle Scholar12. Michaelis LA: Engelmann's disease, Proc. Roy. Soc. Med. (Orthopedic Section) 42: 271, 1949. MedlineGoogle Scholar13. StrangeMcDowell RFHB: A case of Engelmann's disease, J. Bone and Joint Surg. 32-B: 38, 1950. CrossrefGoogle Scholar14. JacksonHanelinAlbright WPJF: Metaphyseal dysplasia, epiphyseal dysplasia, diaphyseal dysplasia and related conditions. III. Progressive diaphyseal dysplasia, Arch. Int. Med. 94: 871, 1954. CrossrefGoogle Scholar15. Anderson FG: Engelmann's disease, Brit. J. Radiol. 26: 603, 1953. CrossrefMedlineGoogle Scholar16. SidburySidbury JBJB: Infantile cortical hyperostosis, New England J. Med. 250: 309, 1954. CrossrefMedlineGoogle Scholar17. Weber FP: Osteosclerotic changes due to chronic infection or neoplastic infiltration (secondary marble bones), Lancet 1: 386, 1955. CrossrefGoogle Scholar18. WindholzFoster FSE: Generalized osteosclerosis in disorders of blood formation, Stanford M. Bull. 5: 75, 1947. MedlineGoogle Scholar19. SharnoffBelskyMelton JGHJ: Plasma cell leukemia or multiple myeloma with osteosclerosis, Am. J. Med. 17: 582, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Worth, Texas*Received for publication November 12, 1955.From the Department of Medicine at the Veterans Administration Hospital, McKinney, Texas, and University of Texas Southwestern Medical School, Dallas, Texas.Requests for reprints should be addressed to Dewey W. Johnston, M.D., 901 West Leuda, Fort Worth, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review 1 March 1957Volume 46, Issue 3Page: 619-628KeywordsBone densityEtiologyHospital medicineHyperparathyroidismHypothyroidismLesionsPathogenesisPhosphorusSpineSyphilis ePublished: 1 December 2008 Issue Published: 1 March 1957 PDF downloadLoading ...

https://doi.org/10.7326/0003-4819-46-3-619
The Journal of the Korean Orthopaedic Association · 2014 · 0 citations · open access

Intramedullary Osteosclerosis Mimicking Lower Leg Radiating Pain

AbstractIntramedullary osteosclerosis is an uncommon benign condition characterized by endosteal new bone formation in long tubular bone of lower extremity and treatment as well as etiology is unknown. Due to the rarity of this disease, and because there is no specific clinical finding except leg pain, it is difficult to differentiate this entity from other causes presenting similar symptoms. We report on a case of intramedullary osteosclerosis mistaken for radiculopathy from lumbar disease with a review of the literature.

https://doi.org/10.4055/jkoa.2014.49.6.490

Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.

DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.