DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for omphalocele — screening already-approved drugs against its 5-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleOmphalocele maps to a 5-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for omphalocele is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
filamin A (FLNA) — FLNA is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet diodrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 2J3S · 2.5 Å · ligand 1,4-DIETHYLENE DIOXIDE (DIO). Experimental structure, not a prediction.
What the evidence adds up to
A retrospective review of 10 patients with omphalocele major treated between 1990 and 2005 in Saudi Arabia used a technique in which the sac was preserved and used as autogenous supportive material. Complete reduction was achieved in all cases in the first stage, followed by surgical closure. No mortality related to the intervention was reported.
A 2021 study of 68 patients (32 female, 36 male) treated with mesh fixation to skin with preserved omphalocele sac reported that 44 (64.7%) had giant omphalocele and 20 (29.4%) had isolated omphalocele. Mortality was 26.5% (18 of 68). Among survivors, 21 (42%) had detached mesh, adhesion bands occurred in 4 (8.2%), and sepsis in 11.8%. The authors concluded the technique had several benefits including shorter hospital stay and duration of intubation compared to previous techniques.
A 2017 study of 11 neonates with giant omphalocele treated with an umbrella repair technique reported mean age at operation of 2.18 days and mean weight of 2150 grams. The umbrella repair group had significantly less operative time and fewer surgeries in the neonatal period compared to conventional methods. Post-operative complications, morbidity, and mortality were also less in the umbrella repair group.
What remains missing is prospective randomised comparison of these techniques against standard staged reduction or primary closure, long-term follow-up data on abdominal wall function and cosmetic outcome, and stratification by associated anomalies, which are common in omphalocele and heavily influence survival. No trial has yet established which surgical approach reduces mortality in the highest-risk giant omphalocele subgroup.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Saudi Medical Journal · 2007 · 0 citations
Management of omphalocele using the sac as supportive material
AbstractOBJECTIVE: To document retrospectively the outcome of a newly modified procedure for closure of large omphalocele, where the sac was conserved and used as autogenous supportive material. METHODS: The medical records of 10 patients with omphalocele major admitted to Al-Noor Specialist Hospital in Makkah, Kingdom of Saudi Arabia in the last 15 years, October 1990 to October 2005, were retrospectively reviewed. The defects were considered by the same treating surgeon too big to be closed primarily so the sac was preserved to reduce the contents gradually. RESULTS: In the first stage, complete reduction was achieved in all the cases followed by second stage, the surgical closure. There was no mortality related to this intervention. CONCLUSION: This proposed technique is safe, simple and effective for the treatment of large omphalocele.
Iranian Journal of Pediatric Surgery · 2021 · 0 citations · open access
Evaluation of Omphalocele Treatment Using New Surgical Technique
AbstractIntroduction: The aim of this study was to evaluate a new technique for treatment of omphalocele using mesh fixation to skin with preserved omphalocele sac.
Materials and Methods: Chart of patients who treated with mesh fixation were reviewed. Demographic features, mortality and morbidity following treatment were recorded.
Results: in the current study 68 patients (f=32, m=36) were included. Of 68 csaes, 44(64.7%) had giant omphalocele. Among all cases, 20(29.4%) had isolated omphalocele. Mortality was 26.5%(18 of 68). Of survived cases, 21(42%) had detached mesh. Adhesion band was seen in 4(8.2%) of cases. Sepsis was seen in 11.8% of the cases.
Conclusion: According to the result of the study, suggested technique is promising and had several benefits. Duration of hospital staying, duration of intubation was less than previous techniques
DOAJ (DOAJ: Directory of Open Access Journals) · 2017 · 0 citations · open access
Umbrella repair of giant omphalocele, A new technique.
AbstractIntroduction: Although many techniques have been described for reconstruction of the giant omphalocele, we present a simple , effective and safe new technique.\n\nMaterials and Methods: We have studied 11 neonates with giant omphalocele that were treated by a new technique, Umbrella repair, in Sarvar pediatric hospital of Mashhad, Iran. In this new technique we released the skin around the omphalocele membrane just near the junction and a purse string suture is placed at the edge of the skin with beads beneath each bite and graded tightening of the suture in order to pushing the omphalocele toward the abdominal cavity. Finally we compare the results.\n\nResults: Among total 11 patients, mean age and weight at the time of operation were 2.18 days and 2150 grams respectively. comparing the results between groups, we observed significant less operative time and number of surgeries in neonatal period among patients who managed by umbrella repair. Post-operative complications, morbidity and mortality in umbrella repair group were also less than coventional methods.\n\nConclusion: Umbrella repair provide a rapid and safe method for management of giant omphalocele with acceptable results and low morbidity and mortality.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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