DeCure for Nutritional deficiency disease

A 2021 study of 20 young women three years after hospital treatment for severe restrictive anorexia nervosa found that 60% were recovered or in partial remission. Despite this, 30% still had subnormal body fat and 25% had subnormal skeletal muscle mass. Mean energy intake was 1730 kcal/day, and 80% consumed less than estimated needs. Micronutrient intakes from food were low: 85% had intakes below recommendations for iron, folate, and vitamin D. Serum levels of vitamins A, E, D, and folate were on average adequate, but 20% had subnormal vitamin D (<50 nmol/L). Ferritin levels were significantly lower at follow-up, with 25% below the reference range. Return of menstruation depended on energy intake and body fat.

A 2021 cross-sectional study of 217 patients with chronic kidney disease (112 with pre-dialysis stages 3-5, 33 on haemodialysis, 72 with kidney transplant) found that patients were prescribed an average of nine medications concurrently. The number of prescribed medications was inversely associated with mid-upper arm circumference, triceps skinfold thickness, handgrip strength, serum albumin, and haemoglobin after adjustment for age, sex, and kidney function. Prescription of medications with nausea as a side-effect showed similar associations; prescription of medications with xerostomia as a side-effect was associated with lower handgrip strength.

A 1989 review noted that the incidence of nutritional deficiencies in hospitalised patients is often high, and that indications for nutritional support are controversial and difficult to define. It described three groups: patients with pre-existing weight loss, low plasma albumin, muscle wasting, and peripheral oedema; patients with no overt malnutrition but a history of reduced intake for 2-4 weeks before admission; and patients with normal nutritional status whose underlying pathology will cause malnutrition if support is withheld. A 1954 article observed that classic deficiency diseases such as scurvy, rickets, beriberi, and pellagra are rarely encountered in the United States and readily treated, but that the role of nutrition in patient management has often been neglected because nutritional status was difficult to appraise. A 1942 book on nutritional deficiencies diagnosis and treatment is noted. A 2025 article argues that many conditions believed to be genetic are actually caused by long-term deficiencies in vitamins, minerals, enzymes, and cellular signalling molecules, and that restoring missing micronutrients can normalise conditions previously labelled as genetic.

What is still missing: large prospective trials that track nutritional status and supplementation in defined patient populations, validated biomarkers for subclinical deficiency states, and randomised controlled trials testing whether correcting specific deficiencies reverses clinical phenotypes currently attributed to genetic causes. The 2025 article’s claims about reversing genetic-like conditions lack published clinical data with measurable outcomes.