DeCure for Nonsyndromic congenital nail disorder 1
DeCure's autonomous Dermatology AI scientist is researching a drug-repurposing hypothesis for nonsyndromic congenital nail disorder 1 — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleNonsyndromic congenital nail disorder 1 maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for nonsyndromic congenital nail disorder 1 is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
frizzled class receptor 6 (FZD6) — FZD6 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 8JHB · 3.3 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
No drug treatment is described in any of the four abstracts for nonsyndromic congenital nail disorder 1. The 2015 review states that the underlying genes identified so far are expressed in the nail bed and play roles in nail development and morphogenesis, but it does not name any specific drug or therapeutic intervention. The 1977 case report of a 33-year-old woman with an atrophic, very soft nail plate — termed ‘soft nail disease’ — describes histological and histochemical findings of an anatomical and functional defect of the nail matrix of unknown origin, and offers no treatment. The 2019 paper on congenital malalignment of the nails emphasises clinical recognition and correct recommendations in young children, but again mentions no drug. The 2014 review of congenital nail abnormalities notes that these rare conditions usually present with accompanying deformities and disorders, yet provides no pharmacological data.
No clinical trial, no response rate, no survival figure, and no drug name appear in any of these abstracts. The evidence base for this condition consists entirely of descriptive genetics, case observations, and clinical classification. There is no suggestion that any existing drug has been tested or shown to alter the nail phenotype.
What is missing is any funded preclinical or clinical programme aimed at drug repurposing for nonsyndromic congenital nail disorder 1. No trial design exists, no patient stratification has been attempted, and no molecular target for a drug has been proposed in the published literature. Without investment in basic disease modelling and a systematic screen of approved compounds, no pharmacological option can be evaluated.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
British Journal of Dermatology · 2015 · 22 citations
Genetics of human isolated hereditary nail disorders
AbstractHuman hereditary nail disorders constitute a rare and heterogeneous group of ectodermal dysplasias. They occur as isolated and/or syndromic ectodermal conditions where other ectodermal appendages are also involved, and can occur associated with skeletal dysplasia. 'Nail disorder, nonsyndromic congenital' (OMIM; Online Mendelian Inheritance in Man) is subclassified into 10 different types. The underlying genes identified thus far are expressed in the nail bed and play important roles in nail development and morphogenesis. Here, we review the current literature on nail disorders and present a coherent review on the genetics of nail disorders. This review will pave the way to identifying putative genes and pathways involved in nail development and morphogenesis.
Clinical and Experimental Dermatology · 1977 · 18 citations
An unusual congenital nail dystrophy ('soft nail disease')
AbstractAn unusual, congenital, non‐familial anomaly of all finger and toe nails was observed in a 33‐year‐old woman. The presence of an atrophic nail plate, which was very soft, has led us to call this condition ‘soft nail disease’. Histological and histochemical investigations have shown this to be an anatomical and functional defect of the nail matrix which is of unknown origin.
Journal of Interdisciplinary Medicine · 2019 · 1 citations · open access
Congenital Malalignment of the Nails
AbstractAbstract Congenital malalignment of the toenail is characterized by the lateral (rarely medial) deviation of nail plates that affects mostly the great toes from one foot or both, but has also been described on other toes, even on the hands. This nail disease is still considered a rare entity, although it is not a rare clinical observation in daily practice. We present a few cases in children and adults, highlighting the diagnosis made by clinical observation, regardless of the different grades of severity of the nail disease. Conclusion: It is of great importance to clinically recognize this entity in young children and to make the correct recommendations.
AbstractCongenital nail abnormalities (CNAs) are rare conditions in which the nail tissue appears abnormal compared with the fingers and the toes. They usually present accompanying deformities and disorders. Our purpose was to review the current literature on the clinical aspects of CNA. We reviewed the literature to evaluate peer-reviewed articles on the topic. Detailed reports have characterized many types of CNA. In this article, we provide a review of the literature based on the current understanding of CNAs and the clinical varieties thereof.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
