DeCure for Multiple benign circumferential skin creases on limbs
DeCure's autonomous Dermatology AI scientist is researching a drug-repurposing hypothesis for multiple benign circumferential skin creases on limbs — screening already-approved drugs against its 2-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleMultiple benign circumferential skin creases on limbs maps to a 2-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for multiple benign circumferential skin creases on limbs is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
tubulin beta class I (TUBB) — TUBB is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet adpdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 7TTT · 2.9 Å · ligand ADENOSINE-5'-DIPHOSPHATE (ADP). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
American Journal of Medical Genetics · 2002 · 16 citations
A second patient with MCA/MR syndrome with multiple circumferential skin creases
AbstractSymmetrical congenital circumferential skin creases are a rare feature described in only a few conditions. We report a case of a 29-month-old boy with symmetrical circumferential skin creases on arms, legs, and digits, and other features reminiscent of the single case reported by Cohen et al. [1993: Clin Dysmorphol 2:39-46] and reviewed by Elliott et al. [1996: Am J Med Genet 62:23-25]. The key features also include epicanthic folds, microphthalmia, microcornea, microcephaly, small, low-set posteriorly angulated ears with thick overfolded helices, cleft palate, and moderate-severe psychomotor developmental delay.
Canadian Prosthetics & Orthotics Journal · 2019 · 12 citations · open access
The influence of perforated prosthetic liners on residual limb wound healing: a case report
AbstractCASE DESCRIPTION: Good residual limb skin health is vital to successful prosthetic prescription. Unnatural loading profiles and excessive sweating can lead to skin and soft tissue problems. Perforated liners allow the transport of moisture away from the skin and allow negative pressure (a condition that has been shown to aid wound healing) to act directly on the residuum surface. AIM: Assess the effects of perforated prosthetic liner use, particularly with respect to wound healing. METHOD: Three patient histories were retrospectively reviewed following prescription of perforated prosthetic liners due to excessive sweating or prolonged residual limb health concerns. Photographic records from patient files were used to document changes in residual limb condition. Patients also provided subjective feedback regarding their experiences. FINDINGS: Two cases described active amputees with persistent blistering irritated during exercise. Another case described a patient of low mobility level with a history of residual limb skin infections. All saw their conditions heal and reported a reduction in problematic sweating. Two patients reported cancelling surgical interventions after substantial improvements with the perforated liner. DISCUSSION: These findings provide evidence that the use of perforated prosthetic liners allow improvements in residual limb health, while still permitting prosthetic use. LAYMAN’S ABSTRACT For lower limb amputees, excessive sweating is a common issue affecting their quality of life. It is particularly problematic for the skin of the amputated limb, which may be scarred and is loaded unnaturally by the prosthetic socket. Silicone liners are often worn to provide a close fit and for cushioning but they create a warm environment that traps sweat against the skin, leading to bacterial growth. Additionally, sweat on the skin can increase the amount of movement between the amputated limb and the socket, affecting prosthetic control. In order to address this problem, silicone liners have been designed with perforations in them to allow warm air and sweat to move away from the skin. This report describes three cases of patients who suffered from long-standing wounds, blisters or skin infections on their amputated limbs. Each was prescribed with a perforated silicone liner and changes in their skin conditions were observed. In all cases, the wounds healed and each patient reported a noticeable reduction in problematic sweating on their residual limb, without limiting their prosthetic use. Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32723/25281 How to Cite: McGrath M, McCarthy J, Gallego A, Kercher A, Zahedi S, Moser D. The influence of perforated prosthetic liners on residual limb wound healing: a case report. Canadian Prosthetics & Orthotics Journal. 2019; volume2, Issue1, No.3. https://doi.org/10.33137/cpoj.v2i1.32723 CORRESPONDING AUTHOR:Dr. Michael McGrath, Research Scientist–Clinical Evidence Blatchford Group, Unit D Antura, Bond Close, Basingstoke, RG24 8PZ, United Kingdom Email: [email protected]
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
