DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for laurin-Sandrow syndrome — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleLaurin-Sandrow syndrome maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for laurin-sandrow syndrome is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
sonic hedgehog signaling molecule (SHH) — SHH is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet y01drag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 7E2I · 4.07 Å · ligand CHOLESTEROL HEMISUCCINATE (Y01). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Journal of Craniofacial Surgery · 2017 · 3 citations
Early Surgical Correction of the Nasal Deformity in Laurin–Sandrow Syndrome
AbstractLaurin-Sandrow syndrome (LSS) is a rare autosomal disorder characterized by polysyndactyly of the hands and feet in a mirror fashion, absence of the radius and tibia with duplicated ulna and fibula, and nasal anomalies. Nasal defects are varied, and range from hypoplastic nasal skeleton to redundant nasal tissue, along with abnormalities of nasal subunits. Only 14 patients of LSS have been described in the literature. The authors present a unique case of a newborn with LSS and anterior nasal stenosis, resulting in respiratory failure. Early surgical intervention to relieve the bony and soft tissue overgrowth of the anterior nasal vault was required to allow for successful extubation.
Pan African Medical Journal · 2021 · 0 citations · open access
Laurin-Sandrow syndrome
AbstractPolydactyly is a typical abnormality, happening both as a segregated deformity or as component of a syndrome. The presence of mirror polydactyly, however, is rare. One such feature is seen in Laurin-Sandrow syndrome (LSS). Laurin-Sandrow syndrome (LSS) is characterized by complete polysyndactyly of hands, mirror feet and nose anomalies (hypoplasia of the nasal alae and short columella), often associated with ulnar or fibular duplication (and sometimes tibial agenesis). This image describes a case of 2-year-old boy, who came to the clinic with complaints of cough and cold for 1 week duration. The Child was alert, active and feeding well. The child was born at term by normal delivery to a healthy parent. Antenatal period was normal. No systematic illness occurred in the neonatal period. On Examination, there was cup shaped hands with syndactyly on the fingers extending upto the tip. Polysyndactyly was present in the feet, with nine digits on the right foot and ten on the left. Conspicuous nose with short columella, depressed nasal bridge, underdeveloped nasal alae. There are not many cases of LSS revealed in the literature. Hence there are no clear insights regarding the etiopathogenesis. Laurin-Sandrow syndrome is supposed to be an autosomal dominant disorder and the gene associated is said to be limb development membrane Protein 1(LMBR1). The child was treated for cold and referred to an orthopedician and pediatrician for further management with respect to LSS.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
