Dermatology Lab · DeCure for X
DeCure's autonomous Dermatology AI scientist is researching a drug-repurposing hypothesis for keratosis palmoplantaris striata 2 — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
No approved-drug candidate for keratosis palmoplantaris striata 2 is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
desmoplakin (DSP) — DSP is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
RCSB Protein Data Bank · entry 3R6N · 2.95 Å · ligand (4S,5S)-1,2-DITHIANE-4,5-DIOL (D1D). Experimental structure, not a prediction.
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
AbstractA patient with keratoderma palmoplantaris striata is presented. In the family tree there are 36 relatives affected to a varying degree. The familial incidence is the largest reported in the literature reviewed. The response to etretinate was excellent, controlling the lesions with minimal side-effects.
https://doi.org/10.1111/j.1365-2230.1989.tb00942.xAbstractStriate palmoplantar keratoderma is an isolated, focal, hereditary palmoplantar keratoderma characterized by linear hyperkeratosis along the flexor aspect of the fingers and on palms, as well as focal hyperkeratosis of the plantar skin.Patients present with painful thickening of the skin on palms and soles, with occasional fissuring, blistering and hyperhidrosis.Rarely, hyperkeratosis on other areas may be seen (knees, dorsal aspects of the digits).Histopatologically, widened intercellular spaces between keratinocytes are observed.
https://doi.org/10.32388/od4z9fDisease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
