DeCure for Infantile hypertrophic pyloric stenosis
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for infantile hypertrophic pyloric stenosis — screening already-approved drugs against its 6-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleInfantile hypertrophic pyloric stenosis maps to a 6-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for infantile hypertrophic pyloric stenosis is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
apolipoprotein A1 (APOA1) — APOA1 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 9PVY · 2.15 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
Infantile hypertrophic pyloric stenosis (IHPS) is a common condition in infancy defined by an acquired narrowing of the pylorus, presenting with projectile nonbilious vomiting, a palpable abdominal 'olive', and sometimes a visible peristaltic wave after feeding. Its cause is largely unknown, and surgical intervention is the standard treatment, with preoperative preparation considered essential for optimal outcome. A 2014 review discusses epidemiology, aetiology, diagnostics, and treatment but does not report any drug therapy or non-surgical intervention.
A 1951 case report describes hypertrophic pyloric stenosis in adults as a separate entity, noting over 100 cases in the literature at that time. It provides no data on drug treatment, survival, or response rates for any population.
A 1998 survey by the Korean Association of Pediatric Surgeons collected data on clinical manifestations and current management preferences from 33 members, but the abstract gives no numerical results for any treatment.
A 2024 retrospective study of babies operated on for IHPS in a neonatal intensive care unit between 2000 and 2022 found that 9.8% of patients had an accompanying rare disease. The authors conclude that early diagnosis and treatment of these associated rare diseases is important for reducing morbidity and mortality, but the abstract reports no drug efficacy data for IHPS itself.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Advances in infantile hypertrophic pyloric stenosis
AbstractInfantile hypertrophic pyloric stenosis (IHPS) is a common condition in infancy, characterized by an acquired narrowing of the pylorus, which requires surgery. These infants usually present with projectile, nonbilious vomiting, with a palpable 'olive' in the abdomen and sometimes a 'peristaltic wave' after being fed with formula or breast milk. Although IHPS is a common disorder, its etiology is largely unknown. Surgical intervention is the standard treatment, preoperative preparation, however is essential to optimal outcome. In this review, the latest advances in IHPS regarding epidemiology, etiology, diagnostics and treatment will be discussed.
AbstractCase Reports1 February 1951HYPERTROPHIC PYLORIC STENOSIS IN ADULTSHERBERT GREENFIELD, M.D., F.A.C.P.HERBERT GREENFIELD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-2-492 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypertrophic pyloric stenosis in infants is a common and well established entity. Hypertrophic pyloric stenosis in adults is achieving increasing publicity as reports begin to trickle into the literature. Over 100 cases thus far reviewed stress its more than academic importance. The importance of bringing to the attention of clinicians and roentgenologists another condition of differential significance in the difficult pyloric segment, justifies the addition of two more cases to the literature.HISTORICThe first note of an adult case of hypertrophic pyloric musculature is found in the autopsy report of a 72 year old woman by Jean Cruveilhier.1A...Bibliography1. Cruveilhier J: Anatomie pathologique du corps humain, ou descriptions avec figures lithographiées et coloriées, des diverses altérations morbides dont le corps humain est susceptible, Tome ler, Paris, J. B. Baillière, 1829. Google Scholar2. Maier R: Beiträge zur angebornen Pylorusstenose, Arch. f. path. Anat. 102: 413, 1885. CrossrefGoogle Scholar3. Maylard AE: Congenital narrowness of the pyloric orifice a cause of chronic gastric disease in the adult, illustrated by seven cases successfully treated by operation, Brit. M. J. 1: 416, 1904. CrossrefMedlineGoogle Scholar4. KirklinHarris BRMT: Hypertrophy of pyloric muscle of adults, Am. J. Roentgenol. 29: 437, 1933. Google Scholar5. JuddThompson ESHL: Hypertrophic stenosis of pylorus in adults, S. Clin. North America 13: 801, 1943. Google Scholar6. Horton BF: Pyloric musculature with special reference to pyloric block, Am. J. Anat. 41: 197, 1928. CrossrefGoogle Scholar7. Wakefield H: Hypertrophic pyloric stenosis in adults, Gastroenterology 2: 4, 1944. Google Scholar8. BerkDunlap JEHJ: Pyloric stenosis in adults, Ann. Surg. 119: 124, 1944. CrossrefMedlineGoogle Scholar9. Katz BA: Hypertrophic pyloric stenosis in adults, Am. J. Digest. Dis. 14: 85-88 (March) 1947. CrossrefMedlineGoogle Scholar10. Crohn BB: Congenital pyloric stenosis in adult life, J. A. M. A. 90: 197, 1928. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Newark, New Jersey*Received for publication March 10, 1949.From the Department of Medicine of the New York University Post Graduate Hospital, and Medical Service, Newark Beth Israel Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRöntgenuntersuchung des MagensMagen 1 February 1951Volume 34, Issue 2Page: 492-498KeywordsAutopsyGraduate medical educationHospital medicineInfantsMedical servicesStenosis ePublished: 1 December 2008 Issue Published: 1 February 1951 PDF downloadLoading ...
Journal of the Korean Association of Pediatric Surgeons · 1998 · 2 citations · open access
Infantile Hypertrophic Pyloric Stenosis: A Survey by the Korean Association of Pediatric Surgeons
AbstractThirty three members of the Korean Association of Pediatric Surgeons were surveyed to determine the clinical manifestations and current management of infantile hypertrophic pyloric stenosis (IHPS). The members completed a registration form and a questionnaire that indicated their treatment preferenc...
Zeitschrift für Geburtshilfe und Neonatologie · 2024 · 1 citations
Rare Diseases and Syndromes Observed in Newborn Babies with Idiopathic Hypertrophic Pyloric Stenosis
AbstractAIM: Although infantile hypertrophic pyloric stenosis is a multifactorial disease caused by genetic and environmental factors, the role of genetic factors has become more important recently. With this study, we aimed to present rare diseases accompanying infantile hypertrophic pyloric stenosis caused by genetic factors. PATIENTS AND METHODS: This is a retrospective study. Babies who were operated on with the diagnosis of infantile hypertrophic pyloric stenosis in the neonatal intensive care unit between 2000 and 2022 and had additional diseases were included in the study. RESULTS: 9.8% of patients diagnosed with infantile hypertrophic pyloric stenosis had an accompanying rare disease. CONCLUSION: Early diagnosis and treatment of rare diseases associated with infantile hypertrophic pyloric stenosis are of great importance in reducing morbidity/mortality due to these diseases.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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