DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for ileus — screening already-approved drugs against its 17-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleIleus maps to a 17-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for ileus is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
sodium voltage-gated channel alpha subunit 9 (SCN9A) — SCN9A is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
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RCSB Protein Data Bank · entry 7W9K · 2.2 Å · ligand O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine (P5S). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Journal of Clinical Pharmacy and Therapeutics · 2014 · 3 citations
Near-fatal, antihypertensive medication overdose due to post-operative gastric ileus
AbstractWHAT IS KNOWN AND OBJECTIVE: Post-operative gastrointestinal ileus is a common complication that can cause erratic absorption of oral pharmaceuticals. CASE SUMMARY: This is a case of near-fatal, antihypertensive medication overdose due to gastric ileus in a 40-year-old patient following combined kidney-pancreas transplant. After being transitioned from intravenous to oral antihypertensive medications, the patient sustained pulseless bradycardia requiring resuscitative measures. Suspicion of accumulated medication bolus due to gastric ileus was confirmed by supratherapeutic serum labetalol measurement of 493 ng/mL (therapeutic range: 30-180 ng/mL). WHAT IS NEW AND CONCLUSION: Judicious use of oral pharmaceuticals, particularly those with relatively narrow therapeutic ranges, is warranted in patients with post-operative ileus.
International Journal of Surgery Case Reports · 2025 · 0 citations · open access
Strangulated ileus due to anterior enterocele following robot-assisted radical cystectomy: A case report of rare complication managed with minimally invasive surgery1
AbstractINTRODUCTION: The incidence of anterior enterocele following robotic radical cystectomy is reported to be approximately 3 %, making it a rare complication. We experienced a case in which a patient developed an anterior enterocele and strangulated ileus through the urethral excision site, for which intracorporeal anastomosis proved to be an effective treatment under a specific and limited clinical situation. PRESENTATION OF CASE: A 72-year-old woman underwent a robot- assisted radical cystectomy for bladder cancer. At nine months post-operation, she presented with small bowel evisceration resulting from dehiscence of an anterior enterocele accompanied by strangulated ileus. Laparoscopic small bowel resection with intracorporeal anastomosis (IA) was performed. Oral intake of food was resumed on post-operative day 3, and the patient was discharged without complications on post-operative day 10. DISCUSSION: In cases of strangulated ileus with dilated bowel loops, minimally invasive surgery incorporating IA can be safely performed by temporarily utilizing an intestinal bulldog clamp for the bowel, employing indocyanine green fluorescence imaging, and selecting an appropriate anastomotic technique. If an adequate surgical environment is maintained, IA may be a viable option for the treatment of strangulated ileus. CONCLUSION: IA may be a viable option for treating strangulated ileus in a limited situation.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
