DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for gastric ulcer — screening already-approved drugs against its 34-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleGastric ulcer maps to a 34-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for gastric ulcer is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
activity regulated cytoskeleton associated protein (ARC) — ARC is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet acedrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 6TNQ · 1.3 Å · ligand ACETYL GROUP (ACE). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
International Journal of Recent Advances in Science and Technology · 2016 · 2 citations · open access
A REVIEW ON: PEPTIC ULCER
AbstractA peptic ulcer is a sore on the lining of the stomach or duodenum. The two most common types of peptic ulcer are called gastric ulcers and duodenal ulcers. Peptic ulcers are found to be due to an imbalance between aggressive factors such as hydrochloric acid (HCL), pepsin, refluxed bile, leukotrienes (LTs), reactive oxygen species (ROS) and defensive factors, which include the function of the mucus bicarbonate barrier, prostaglandins(PGs), mucosal blood flow, cell renewal and migration, nonenzymatic and enzymatic antioxidants and some growth factors. H. pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) are the predominant causes of peptic ulcer disease. Also a numbers of factors are implicated in the pathogenesis of gastric ulcer, among which major factors involved are bacterial infection (Helicobacter pylori), certain medications (NSAID), chemicals (Hcl/ethanol), gastric cancer and minor factors are stress, smoking, spicy food and nutritional deficiencies. Due to changes in life style and eating habits an increase in frequency to be affected by ulceration in gastric contents can be observed now a day. At the same time a number of semi synthetic and synthetic drugs like proton pump inhibitors, H2 receptor antagonists, and mucosal defensive agents along with various antimicrobial agents are available for the treatment of ulcer.
Journal of Diseases Disorders & Treatments · 2022 · 0 citations · open access
Gastric Ulcer and Surgery
AbstractGastric ulcer is a type of peptic ulcer disease, and peptic ulcers are all ulcers that affect the stomach and small intestine. Gastric ulcer occurs when the thick layer of mucous membrane that protects the human stomach from digestive juices is reduced. This allows the digestive acids to corrode the tissues on the inside of the stomach wall, causing ulcers. Gastric ulcer can be cured, but without proper treatment it can become a serious problem
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
