DeCure for Ganglion or cyst of synovium/tendon/bursa
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for ganglion or cyst of synovium/tendon/bursa — screening already-approved drugs against its 3-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleGanglion or cyst of synovium/tendon/bursa maps to a 3-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for ganglion or cyst of synovium/tendon/bursa is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
RAB38, member RAS oncogene family (RAB38) — RAB38 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet gtpdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 6S5H · 2.0 Å · ligand GUANOSINE-5'-TRIPHOSPHATE (GTP). Experimental structure, not a prediction.
What the evidence adds up to
A retrospective analysis of 1,784 patients with ganglion cysts found a mean age of 34.49 years, 61% female, and 83.4% of cysts in the upper extremity, with 58.9% on the dorsal wrist. Treatment was cyst excision in 36.3% and cyst resection in 23.6%. Recurrence occurred in 27.2% of all patients; among those with recurrence, none underwent a second aspiration, and 33.8% had cyst excision. The study followed patients from at least 6 months to 5 years after primary treatment.
Intratendinous ganglion cysts are described as very rare, with unknown incidence, and present similarly to regular ganglion or giant cell tumours of the tendon sheath. Treatment involves surgical removal of the involved tendon portion, with repair or reconstruction as needed. A separate case report notes that ganglion cysts normally occur in major and weight-bearing joints, and incidence in small joints is uncommon; the patient presented with a cyst at the root of the left index finger, and the authors mention potential risk of injury and infection from trivial trauma, leading to complications like arthritis and septicemia.
No drug treatment is mentioned in any of the abstracts. The evidence is limited to surgical and aspiration outcomes, with a recurrence rate of 27.2% in the largest series. What is missing are prospective trials comparing aspiration, excision, and no intervention, as well as any data on patient stratification by cyst location or size, and funding for such comparative studies.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Journal of Plastic Surgery and Hand Surgery · 2025 · 1 citations · open access
Plastic surgery treatment approaches and results for ganglion cysts: retrospective analysis of 1,784 patients
AbstractINTRODUCTION: Ganglion cysts are tumor-like formations that develop as a result of herniation of synovium around muscles, tendons, and joints. Sometimes recurrence develops after primary treatment and secondary treatment is planned as a result. Objective: The aim of this study was to perform a retrospective analysis of plastic surgery treatment approaches and patient outcomes in 1,784 patients with ganglion cysts. Method: The study type was descriptive and longitudinal. Patients were followed up from at least 6 months to 5 years after the primary ganglion cyst was treated. Data collection was retrospectively extracted from the patient records of the clinic where the study was conducted. Descriptive tests, chi-square test, and post hoc analysis were used for data analysis. Results: The mean age of patients with ganglion cysts in this study was 34.49 ± 8.21 years, 61% were female. 83.4% had ganglion cysts in the upper extremity and 58.9% of them were localized in the dorsal wrist. For treatment, 36.3% underwent cyst excision and 23.6% underwent cyst resection. Recurrence occurred in 27.2% of the total number of patients. None of the patients with recurrence underwent a second cyst aspiration, 33.8% underwent cyst excision. Conclusion: Ganglion cysts were mostly localized to the hand and wrist and needle aspiration may be preferred for diagnosis as it provides a definitive result as to whether the mass is benign or not. Recurrences after surgical excision, resection or joint arthrodesis were found in the literature.
Journal of Orthopaedic Association of South Indian States · 2024 · 0 citations · open access
Intratendinous Ganglion of Extensor Tendon: A Case Report
AbstractAbstract Intratendinous ganglion cysts are very rare and present very similar to regular ganglion or giant cell tumors of the tendon sheath. Much regarding ganglion cysts has not been mentioned in the literature, and incidence is unknown. They can occur over the dorsal and volar aspects of the hand with the former being more common. Treatment involves surgical removal of the involved portion of the tendon and with repair or reconstruction done accordingly.
Journal of Evolution of Medical and Dental Sciences · 2014 · 0 citations · open access
GANGLION CYST IN THE ROOT OF THE LEFT INDEX FINGER
AbstractGanglion cyst is a condition where there is herniation of synovium from the joint space to the exterior and presents as a cystic mass. The cyst can maintain the connection to the joint space. There is potential risk of injury and infection due to even a trivial trauma leading to complications like arthritis and septicemia. The ganglion cysts normally observed in major and weight bearing joints. The incidence in small joints are uncommon. The present patient presented with a cystic lesion in the root of the left index finger.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
