DeCure's autonomous Metabolic AI scientist is researching a drug-repurposing hypothesis for familial gestational hyperthyroidism — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleFamilial gestational hyperthyroidism maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for familial gestational hyperthyroidism is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
thyroid stimulating hormone receptor (TSHR) — TSHR is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet 2sdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 7UTZ · 2.4 Å · ligand (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate (Z41). Experimental structure, not a prediction.
What the evidence adds up to
A 2012 case report describes a 29-year-old woman at 15 weeks gestation with a partial hydatidiform mole, triploidy (69, XXY), and β-hCG values approximating 2,225,000 IU/L. She presented with acute upper abdominal pain, tachycardia, hypertension up to 160/100 mmHg, and double elevated liver enzymes. Her thyroid function showed TSH below 0.1 mU/L and fT4 of 29.6 pmol/L. Hyperthyroid symptoms were managed with methizol and propanolol. Abortion was induced with gemeprost after cervical priming with mifepriston. Clinical improvement followed expulsion of all foetal tissues; β-hCG fell below detection after 12 weeks, and no further thyroid or cardiopulmonary pathology was found at follow-up.
A 2011 population-based study in Taiwan compared 2830 mothers with hyperthyroidism and 14,150 age-matched controls. Women receiving propylthiouracil (PTU) during pregnancy had a higher risk of low birthweight infants than untreated hyperthyroid mothers (odds ratio 1.40; 95% CI 1.00–1.96), after adjusting for maternal education, anaemia, hyperlipidaemia, pregestational diabetes, pregestational hypertension, hyperemesis gravidarum, and infant sex and birth order. Children of women receiving methimazole/carbimazole (MMI) did not show increased risks of low birthweight, preterm birth, small for gestational age, or major congenital anomalies relative to untreated mothers.
A 2017 Moroccan retrospective study notes that gestational hyperthyroidism occurs in approximately one to three per 1000 pregnancies. The dominant causes are Graves’ disease and gestational transient thyrotoxicosis; the first requires antithyroid drug treatment, the second progresses well under symptomatic treatment.
A 2022 study of a Chinese family with Familial Dysalbuminemic Hyperthyroxinemia (FDH) due to the R218H albumin mutation identified eight affected members among thirteen lineal relatives. Affected individuals showed very high total T4, mildly high total T3, normal free T4 and free T3, and normal TSH. Ultrasound revealed diffuse goiter and enhanced blood flow; 99mTc uptake was increased, but TSH receptor antibody and pituitary MRI were normal. TSH could be suppressed by dexamethasone and bromocriptine. Four of the eight had been misdiagnosed with hyperthyroidism and received anti-thyroid medication for at least one year. The study states that FDH exerts no effect on pregnancy.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Zeitschrift für Geburtshilfe und Neonatologie · 2012 · 1 citations
Thyreotoxikose in der Frühschwangerschaft bei partieller Blasenmole – ein Fallbericht
AbstractINTRODUCTION: With an incidence of 1:2,000-1:3,000 in Europe, mole pregnancy is rare. Partial mole is a benign form of gestational trophoblastic disease in which triploidy is thought to be caused by the insemination of an ovum by 2 sperms. A vital embryo is often dystrophic and growth retarded. The disease can present with vaginal bleeding, secondary anaemia, jaundice, signs of gestosis, as well as hyperthyroidism. CASE HISTORY: A 29-year-old, 2G1P, visited our hospital in the 13+3 week of gestation for first -trimester screening of trisomy 21. The patient was re-appointed for an ultrasound scan at 16 weeks of gestation to follow-up the appearance of a -cystic, hyperplasic placenta and minimal foetal pericardial effusion. She appeared at the 15+1 week gestation with acute upper abdominal pain, -tachycardia, hypertension (up to 160/100 mmHg) and double elevated liver enzymes. The performed ultrasound scan revealed a hydratiform placenta along with symmetrical foetal intrauterine growth retardation (IUGR). A cytogenetic examination revealed a triploidy (69, XXY). β-hCG-values approximated 2,225,000 IU/L. Due to the severe progression of hyperthyroid symptoms (TSH<0.1 mU/L and fT4 29.6 pmol/L) and the poor foetal prognosis, abortion was induced with intravaginal supplements of gemeprost after cervical priming with mifepriston. Hyperthyroidism symptoms were managed with methizol and propanolol. The clinical situation improved rapidly following the expulsion of all foetal tissues. Histopathology of all aborted specimens verified the suspected diagnosis of partial mole including a slightly dystrophic fetus. Patient follow-up did not reveal any further pathology of the thyroid nor of the cardiopulmonary situation. β-hCH values sank to below detection levels after 12 weeks. CONCLUSIONS: Gestational trophoblastic disease should be considered in the differential diagnosis when acute onset of symptoms pointing to hyperthyroidism occurs in women of child-bearing age.
Zenodo (CERN European Organization for Nuclear Research) · 2017 · 0 citations · open access
Etiology Of Hyperthyroidism In Pregnancy.
AbstractHyperthyroidism is a common endocrine disorder in young women of childbearing age. Approximately one to three cases of gestational hyperthyroidism occur per 1000 pregnancies. All etiologies of hyperthyroidism may be encountered during pregnancy but they are dominated by Graves\\\' disease and gestational transient thyrotoxicosis. The first requires an antithyroid drug treatment and the second progresses well under symptomatic treatment. Hence the interest of the Establishment of the cause of hyperthyroidism. A retrospective observational study was conducted in Morocco in the city of Laayoune to know the main causes of hyperthyroidism in pregnancy according to gestational age.
Zenodo (CERN European Organization for Nuclear Research) · 2017 · 0 citations · open access
Etiology Of Hyperthyroidism In Pregnancy.
AbstractHyperthyroidism is a common endocrine disorder in young women of childbearing age. Approximately one to three cases of gestational hyperthyroidism occur per 1000 pregnancies. All etiologies of hyperthyroidism may be encountered during pregnancy but they are dominated by Graves\\\' disease and gestational transient thyrotoxicosis. The first requires an antithyroid drug treatment and the second progresses well under symptomatic treatment. Hence the interest of the Establishment of the cause of hyperthyroidism. A retrospective observational study was conducted in Morocco in the city of Laayoune to know the main causes of hyperthyroidism in pregnancy according to gestational age.
Medical Research Frontiers · 2022 · 0 citations · open access
Familial Dysalbuminemic Hyperthyroxinemia Induced by Mutation R218H of Albumin
AbstractFamilial Dysalbuminemic Hyperthyroxinemia (FDH) is thought of no clinical significance, but tends to to misdiagnosed and mistreated as Graves’ hyperthyroidism with long time. In a Chinese family to explore clinical characteristics, hereditary features and gene variation of FDH and its effect on pregnancy. Methods: Two propostitus (a father and his son) with hyperthyroidism were re-diagnosed as FDH due to the canonical profile of measured thyroid hormones. After screening thyroid function of the whole family, eight affected of FDH were identified among total thirteen lineal relatives. They were studied in terms of clinical history, biochemical and hormone examination, thyroid imaging and TSH secreting test by dexamethasone and bromocriptine. Three members accepted gene analysis with the next generation sequencing followed by Sanger method. Productive history was investigated in five spouse of the whole family. Results: In the two propostitus, FDH exhibited very high total thyroxine (T4) and mild high total triiodinethyronine (T3), and normal free T4 and T3 besides normal thyroid stimulating hormone (TSH). In addition, ultrasound discovered diffuse goiter and enhanced blood flow, and 99mTc uptake increased, while TSH receptor antibody and pituitary MRI scan remained normal. Other six family members had similar changes of the thyroid hormones and normal TSH which could be suppressed dramatically by dexamethasone and bromocriptine, then were suspected of FDH and thereafter confirmed with gene analysis. Among these eight FDH, four were misdiagnosed with hyperthyroidism and mistakenly received anti-thyroid medication at least one year. Gene analysis of three members revealed R218H variation of albumin gene. Conclusions: R218H associated FDH shows canonical changes of thyroid hormones with increased thyroid function, high penetrance and misdiagnose rate with hyperthyroidism, it exerts no effect on pregnancy.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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