DeCure for Duane retraction syndrome 3 with or without deafness
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Duane retraction syndrome 3 with or without deafness — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleDuane retraction syndrome 3 with or without deafness maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for duane retraction syndrome 3 with or without deafness is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
What the evidence adds up to
A 2020 prospective interventional study of 31 Duane retraction syndrome patients (age 9 months to 28 years) reported that 13 were left without surgery because they were orthophoric or had minimal misalignment in primary position with mild globe retraction on attempted adduction and no vertical shoot or abnormal head position. The remaining 18 patients received surgery: 9 were exotropic, 8 esotropic, and 1 orthophoric. The study concluded that single muscle recession and simultaneous recession of both medial and lateral recti can correct horizontal strabismus in primary position, globe retraction on adduction, and abnormal head position. Overshoots were managed by lateral rectus Y-splitting or simultaneous recession of both recti, and inferior oblique anteriorisation was used for hypertropia in primary position with slow upshoot. Small lateral rectus resection was used in esotropic cases with mild retraction.
A 2013 case report described a patient with syndromic Duane retraction syndrome who had a chromosome 8 inversion and a marker chromosome containing subregions with differing mosaicism and allele frequencies, highlighting the need for multiple genetic methods to understand genotype–phenotype correlation. A 2014 report described a 5-year-old girl with bilateral familial vertical Duane syndrome with alternating esotropia, elevation deficit, Marcus Gunn phenomenon, facial hypoplasia, and abnormal adducting downshoots on attempted abduction, hypothesising aberrant innervation or peripheral anatomic connections between inferior and medial recti. A 2015 case reported an unreported association between Duane retraction syndrome type 1 and Usher syndrome type 2 (congenital bilateral sensorineural hearing loss and retinitis pigmentosa). A 2020 historical article noted that William F. Hoyt contributed to determining that Duane retraction syndrome is caused by congenital absence of the sixth nerve combined with innervation of the lateral rectus by branches of the third nerve.
No drug treatment is mentioned in any of these abstracts. The 2020 surgical study had a 6-month follow-up and did not report long-term outcomes or controlled comparisons. What is still missing are randomised trials comparing surgical techniques, standardised outcome measures for patient-reported function, and genetic studies that could stratify patients by molecular subtype to predict surgical response or identify non-surgical targets.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Clinical Case Reports · 2013 · 4 citations · open access
Complex cytogenetic rearrangements at the <scp>DURS</scp>1 locus in syndromic Duane retraction syndrome
AbstractKey Clinical Message A patient with syndromic Duane retraction syndrome harbors a chromosome 811.1q13.2 inversion and 8p11.1‐q12.3 marker chromosome containing subregions with differing mosaicism and allele frequencies. This case highlights the potential requirement for multiple genetic methods to gain insight into genotype–phenotype correlation, and ultimately into molecular mechanisms that underlie human disease.
Oman Journal of Ophthalmology · 2014 · 3 citations · open access
Bilateral familial vertical Duane Syndrome with synergistic convergence, aberrant trigeminal innervation, and facial hypoplasia
AbstractA 5-year-old girl presented with bilateral familial vertical Duane retraction syndrome with alternating esotropia, elevation deficit, Marcus gunn phenomenon, and facial hypoplasia. Abnormal adducting downshoots on attempting abduction suggestive of a synergistic convergence were noted. Hypothesis suggests aberrant innervations or peripheral anatomic connections between inferior and medial recti.
Duane Retraction Syndrome Type 1 With Usher Syndrome Type 2: An Unreported Association
AbstractDuane retraction syndrome is characterized by globe retraction and palpebral fissure narrowing on adduction, with restriction of abduction, adduction, or both. Usher syndrome type 2 consists of congenital bilateral sensorineural hearing loss and retinitis pigmentosa. The authors present a case with a yet unreported association between Duane retraction syndrome type 1 and Usher syndrome type 2.
Journal of Neuro-Ophthalmology · 2020 · 2 citations
William F. Hoyt's Role in Identifying the Pathogenesis of Duane Retraction Syndrome
AbstractFor many years, it was unclear whether Duane retraction syndrome was a myopathic or neuropathic condition. This article describes the direct and indirect contributions of William F. Hoyt, MD, to the eventual determination that the condition is caused by a congenital absence of the sixth nerve combined with innervation of the lateral rectus muscle by branches of the third nerve.
Egyptian Journal of Clinical Ophthalmology · 2020 · 0 citations · open access
MANAGEMENT OF DUANE RETRACTION SYNDROME
AbstractPurpose: To determine the clinical profile of various subtypes of Duane retraction syndromepatients and to evaluate different surgical strategies in correction of different clinical signs.Patients and Methods: This was a hospital-based prospective interventional study conductedat the Ophthalmology department, Al-Azhar university hospital in Assiut over a duration of twoyears from October 2017 to October 2019. Thirty one patients of DRS were scheduled to beincluded in this study. They were divided into three groups; Group I: 21 patients of DRS type I,Group II: 4 patients of DRS type II and Group III: 6 patients of DRS type III. Age of patientsranged from 9 months to 28 yrs old. Postoperative results were evaluated over 6th monthsfollow-up period. Results: Thirteen patients were left without surgical intervention, they wereorthophoric or with minimal misalignment in PP with mild retraction of the globe on attemptedadduction and none of them had any vertical shoot nor abnormal head position, eighteen patients ofDRS had surgical intervention. Nine cases were exotropic, 8 cases were esotropic & 1 case wasorthophoric. Horizontal deviations were managed with unilateral or bilateral muscle recession&simultaneous recession of MR & LR. Retraction of the globe was managed with single musclerecession or simultaneous recession of both MR & LR. Vertical shoots were managed with LRY-splitting, IO recession& simultaneous recession of both MR& LR. Conclusion: Every patientof Duane retraction syndrome has an individual story, with good diagnosis & accurate grading todifferent signs we can determine the best surgical technique for the correctable signs. Singlemuscle recession & simultaneous recession of both MR & LR can correct horizontal strabismusin PP, the retraction of the globe on attempted adduction & the abnormal head position effectively.Overshoots can be corrected by LR Y-splitting, simultaneous recession of both MR& LR IOanteriorisation surgery is the best choice in cases with HT in PP & slow upshoot. Small LR resectioncan be done in esotropic cases with mild retraction (grade 1).
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
