DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Disseminated Peritoneal Leiomyomatosis — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleDisseminated Peritoneal Leiomyomatosis maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for disseminated peritoneal leiomyomatosis is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
mediator complex subunit 12 (MED12) — MED12 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 8TQ2 · 3.8 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
A 2016 case report describes a patient who presented with disseminated peritoneal leiomyomatosis ten years after laparoscopic myomectomy. At laparotomy the uterus was enlarged with fibroids and densely adherent to the bladder, omentum and sigmoid colon; multiple tumours of different sizes were attached to the peritoneum, omentum and bowel. The report notes that this was the first case in the literature in which the condition was associated with ascites and lymph node enlargement. The authors propose that smooth muscle cells lost in the abdominal cavity during electrical morcellation may progress to disseminated peritoneal leiomyomatosis even after many years.
A 2021 imaging report states that the condition is a rare benign entity characterised by multiple smooth muscle implants in the peritoneal cavity. Clinical presentation is usually non-specific abdominal discomfort and a non-tender abdominal mass. The authors note that preoperative imaging often suggests malignancy because of the unusual location, but that diagnosis can only be confirmed by histopathological examination. No treatment or outcome data are provided in that report.
A 2022 case report describes disseminated peritoneal leiomyomatosis diagnosed in a 36-year-old woman. The report provides no treatment details, no survival data, and no response rates. It is a single-patient description with no follow-up information.
Across these three reports, no drug therapy is mentioned, no clinical trial is described, and no comparative outcome data exist. What is missing is any prospective study, any randomised trial, any systematic collection of treatment responses, and any stratification of patients by hormone receptor status or prior surgical history. Without these, the natural history of the condition and the effect of any intervention remain unknown.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
International Journal of Surgery Case Reports · 2016 · 24 citations · open access
Leiomyomatosis Peritonealis Disseminata (LPD) ten years after laparoscopic myomectomy associated with ascites and lymph nodes enlargement: a case report
AbstractINTRODUCTION: We report a case of leiomyomatosis peritonealis disseminata (LPD) arising 10 years after a laparoscopic myomectomy that was associated with ascites and lymph nodes enlargement. PRESENTATION OF CASE: The patient presented with small uterine fibroids with a dominant posterior intramural fibroid measuring 9cm in diameter and normal Doppler. Laparotomy revealed a uterus enlarged with fibroids, which was densely adhering to the urinary bladder, greater omentum, and sigmoid colon. Multiple tumors of different size were found attached to the peritoneum, omentum and bowel. The histopathologic examination was consistent with leiomyomatosis peritonealis disseminata. DISCUSSION: Pieces of smooth muscle cell lost in the abdominal cavity during electrical morcellation after laparoscopic myomectomy may progress to leiomyomatosis peritonealis disseminata even after many years (ten in our case) and it can be associated with ascites and lymph nodes enlargement. CONCLUSION: This is the first case reported in literature of leiomyomatosis peritonealis disseminata with these particular features (time of clinical presentation, ascites, lymph nodes enlargement).
World Journal of Nuclear Medicine · 2021 · 5 citations · open access
18F-fluorodeoxyglucose positron emission tomography-computed tomography imaging of leiomyomatosis peritonealis disseminata
AbstractAbstract Leiomyomatosis peritonealis disseminata (LPD) is a rare benign condition characterized by multiple smooth muscle implants in the peritoneal cavity. The clinical presentation is usually nonspecific abdominal discomfort and nontender abdominal mass. Preoperative imaging usually points to suggests malignancy due to its unusual location, but the diagnosis can only be confirmed by histopathological examination. We share 18F-Fluorodeoxyglucose positron emission tomography-computed tomography images of a 43-year-old woman diagnosed with LPD and briefly discuss the clinical aspects of this disease.
Scholars Journal of Medical Case Reports · 2022 · 1 citations · open access
Disseminated Peritoneal Leiomyomatosis: A Case Report and Review of the Literature
AbstractLeiomyomas are benign tumours consisting of a proliferation of smooth muscle cells. Extra uterine localisations are rare. Disseminated peritoneal leiomyomatosis corresponds to the localisation of these tumours within several tissues of the body. We report a case of disseminated peritoneal leiomyomatosis diagnosed in a 36-year- old woman.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
