DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Digestive System Adenoma — screening already-approved drugs against its 3-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleDigestive System Adenoma maps to a 3-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for digestive system adenoma is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
KRas proto-oncogene, GTPase (KRAS) — KRAS is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet gnpdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 7VVB · 1.7 Å · ligand PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER (GNP). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Humana Press eBooks · 2003 · 1 citations
Neurologic Complications of Gastrointestinal Malignancies
AbstractGastrointestinal malignancies as a group are the third most common systemic cancer and make up almost 20% of all new cancer diagnoses. The majority of these cases are colorectal adenocarcinomas, with much smaller numbers of other digestive system malignancies contributing to the total. This chapter will review the cancers of the digestive tract, their therapy, and neurologic complications related to the disease or treatment thereof.
Egyptian Pediatric Association Gazette · 2025 · 1 citations · open access
Transumbilical single-site laparoscopic treatment of ileal adenomyoma causing intussusception in child: a rare case report
AbstractAbstract Background Adenomyoma of the digestive tract is a relatively rare benign tumor that predominantly occurs in the stomach and duodenum, with occurrences in the small intestine being exceedingly uncommon. Adenomyomas of the small intestine can lead to complications such as intussusception, intestinal obstruction, and melena or may present without any apparent symptoms. These tumors are particularly rare in pediatric patients. Herein, we report an unusual case of intussusception caused by an ileal adenomyoma in a child. Case presentation A 4-year-old male was admitted to the hospital with abdominal pain and vomiting for 7 h. After coming to our hospital, the patient underwent an abdominal ultrasound examination, which revealed a 10.5 cm × 3.1 cm mass on the left side of the abdomen, with a “target ring”-like sign in its cross-section, and was initially diagnosed with small bowel intussusception. After single-site laparoscopic exploration through the umbilical incision was performed and the small intestine was repositioned via manipulation, a mass measuring approximately 1.5 cm × 1.0 cm × 0.8 cm in size was detected in the lumen of the ileum, and a resection of the ileal mass was carried out, and an ileal adenomyoma was diagnosed via pathology. Conclusions Intussusception, a condition that is both rare and challenging to diagnose preoperatively, is the most common clinical manifestation of small intestine adenomyoma in children. Upon diagnosis, surgical resection remains the optimal treatment option. Transumbilical single-site laparoscopic surgery for treating small intestine adenomyoma complicated with intussusception has been demonstrated to be safe and feasible, making it a promising approach worthy of broader clinical application.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
