DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Dent disease type 1 — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleDent disease type 1 maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for dent disease type 1 is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
Cl-/H+ antiporter 5 (CLCN5) — CLCN5 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet adpdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 2JA3 · 3.05 Å · ligand ADENOSINE-5'-DIPHOSPHATE (ADP). Experimental structure, not a prediction.
What the evidence adds up to
The abstracts provided do not address Dentin dysplasia type 1 or Dent disease type 1. One abstract describes a 2019 case report of a 15-year-old girl with a developmental disturbance of dentin similar to dentin dysplasia type 1d, noting radiographic findings of obliterated pulp chambers, short blunted roots, and multiple periapical radiolucencies. A 2024 case report describes a 19-year-old patient with dentin dysplasia type I confirmed by ground sectioning and microscopic examination, managed with zygoma and endosteal implants. The remaining abstracts concern dentinal hypersensitivity, orthodontic functional appliances, and complete dentures, none of which relate to Dent disease type 1.
No abstract in the set mentions Dent disease type 1, a genetic kidney disorder. There is no evidence for any drug, treatment, or intervention for Dent disease type 1 in these abstracts. The abstracts on dentin dysplasia describe rare dental developmental disorders, not the renal condition Dent disease.
What is missing is any clinical trial, preclinical study, or case series investigating a drug or therapy for Dent disease type 1. No funding, trial design, or patient stratification data exist in these abstracts for that disease.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Australian Dental Journal · 2013 · 26 citations
Clinical efficacy of a herbal dentifrice on dentinal hypersensitivity: a randomized controlled clinical trial
AbstractBACKGROUND: Dentinal hypersensitivity is a common problem and there is a growing interest in herbal based formulations for the treatment of oral diseases. This study was conducted to assess the efficacy of a commercially available novel herbal dentifrice in reduction of dentinal hypersensitivity. METHODS: A total of 73 subjects (38 males and 35 females; aged 25-60 years) were randomly divided into two groups: Group 1 - a placebo dentifrice (The Himalaya Drug Company Research and Development, Makali, Bangalore) and Group 2 - (test group), a commercially available herbal dentifrice (Hi Ora K, The Himalaya Drug Company Research and Development, Makali, Bangalore). Sensitivity scores for controlled air stimulus and cold water were recorded at baseline, 6 weeks and 12 weeks. RESULTS: The test group was found to be significantly better compared to the placebo group at the end of 6 and 12 weeks in reduction of dentinal hypersensitivity. CONCLUSIONS: The novel herbal dentifrice can be recommended for treatment of dentinal hypersensitivity.
International Journal of Clinical Pediatric Dentistry · 2020 · 11 citations · open access
Second Class Functional Treatment: Andreasen Activator vs Twin Block
AbstractThe purpose of this research is to analyze and compare the dental and skeletal changes induced by two functional devices, Andreasen Activator and Clark's twin block, on the sagittal and vertical plane, by means of cephalometric analysis, of the lateral cephalograms prescribed at the beginning and at the end of the treatment for a second skeletal class, first division with normal or deep bite. Materials and methods: Twenty patients, 8 females and 12 males, fulfilling criteria for inclusion, were divided randomly into two groups: group I was treated with Andreasen activator, the second group with Clark's twin block. The duration of the therapy was about 18 months plus less 2 months. Pretreatment and posttreatment cephalometric radiographs were analyzed using angular (SNA, SNB, ANB, SnaSnp-GoGn angles), linear (Sna-Snp, Co-Gn, Co-Go, Go-Gn) skeletal parameters and dental one (U1-SnaSnp angle, L1-GoGn angle, Overjet and Overbite). To evaluate the posttreatment changes in the single groups and between them, paired and unpaired t-test was used. Results: In both of the two groups analyzed, all the sagittal and vertical, angular and linear, skeletal measurements appear to be increased in a statistically significant way, except SNA angle and the distance Sna-Snp. Regarding the dental parameters, in the group treated with Andreasen activator, only Overjet and Overbite showed statistically significant differences. On the other hand, twin block induced statistical changes about Overjet, Overbite and also U1/SnaSnp, but not about L1/GoGn. The advancement of the mandible determines a greater prominence of the chin and lower lip, an increment of the labial mental angle and a reduction of the convexity of the profile. Also, the decrease of the overjet and, consequently, of the dental exposure improve the esthetic appearance of the patient's face. Conclusion: Both functional treatments showed a lower jaw advanced on the sagittal plane and increased in size. In the upper jaw no significant changes were observed. It was also evident a dental compensation both on sagittal and vertical planes. Clinical significance: The functional devices studied, Andreasen activator and twin block, seem to obtain more skeletal than dental results when the patients were treated at the peak of pubertal growth.
Journal of Research in Dentistry · 2015 · 5 citations · open access
Immediate complete denture: a contemporary view
AbstractAIM: The objective of this study was to describe the advantages, disadvantages, indications and some limitations of the Immediate Complete Denture (ICD) treatment. MATERIAL AND METHODS: An electronic and manual search was made in SciELO, SCOPUS, MEDLINE/PubMed databases from 1972 to 2015. Publications in Portuguese, Spanish and English were selected to write this narrative review of the literature. CONCLUSION: Despite the limitations of this study it was conclude that treatment with ICD is the best option because of its satisfactory results.
Improvement of Chewing Ability by Complete Denture: A Case Report
AbstractPATIENT: A 58 year-old female patient visited the clinic with chief complaint of chewing difficulty with her complete dentures. These dentures did not have a sufficient size of denture base and the resin teeth were completely ground down. Treatment dentures were inserted and the form was transferred to final dentures. DISCUSSION: The risk of re-treatment and adjustment after the denture insertion was reduced by using the treatment dentures. The Cochrane Library reported that there is no difference between complete dentures and implant supported over dentures in terms of patient satisfaction/chewing ability, provided the patient has an adequate mandibular ridge. CONCLUSION: Treatment dentures are important to reduce the risk of re-treatment.
Journal of Research in Dental and Maxillofacial Sciences · 2019 · 0 citations · open access
Developmental Disturbance of Dentin with Probable Diagnosis of Dentin Dysplasia Type 1d: A rare case report
AbstractBackground and Aim: Dentin dysplasia (DD) is a rare disturbance of dentin formation, characterized by normal enamel but atypical dentin formation with abnormal pulpal morphology. In DD type I, the teeth appear clinically normal in morphologic appearance and color. Radiographic analysis shows obliteration of all pulp chambers as well as short, blunted, and malformed or absent roots with multiple periapical radiolucencies involving apparently intact teeth. Case Presentation: We present a case of a 15-year-old girl with a developmental disturbance of dentin similar to DD type 1. Radiographic examination revealed multiple affected teeth with unique findings in accordance with DD 1d subtype. This article highlights the clinical and radiographic findings of this condition along with the differential diagnosis and management.
A Novel Approach to the Management of Dentin Dysplasia Using Zygoma Implants: A Case Report
AbstractDentin dysplasia (DD) is a rare clinical entity that can affect deciduous dentition alone, or both deciduous and permanent dentition. It is a developmental disorder that can be classified as DD type I or type II. This case report describes a rare case of DD type I in a 19-year-old patient, highlighting the clinical presentation and the radiographic features of the condition, confirmed by ground sectioning and microscopic examination of extracted teeth. The case report also describes the management of this patient using zygoma and endosteal implants.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
