DeCure's autonomous Dermatology AI scientist is researching a drug-repurposing hypothesis for contact dermatitis — screening already-approved drugs against its 29-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleContact dermatitis maps to a 29-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for contact dermatitis is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
ficolin 1 (FCN1) — FCN1 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet ipadrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 2JHM · 1.52 Å · ligand ISOPROPYL ALCOHOL (IPA). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Indian Journal of Dermatology · 2020 · 6 citations · open access
Epidemiological pattern of contact dermatitis among urban and rural Patients attending a tertiary care center in a semi-urban area in Eastern India
AbstractBACKGROUND: There is a trend of increase in number of contact dermatitis cases. Studies on the prevalence and epidemiological pattern of allergic skin disorders in Indian scenario are not much available. The present study was designed to assess the epidemiological pattern of contact dermatitis in rural and urban areas in a peripheral district in eastern India. AIMS AND OBJECTIVES: This study was undertaken to find the prevalence of contact dermatitis and to assess the epidemiological pattern of contact dermatitis both in rural and urban community. MATERIALS AND METHODS: The study was conducted in a medical college located at a semi-urban area in eastern India with written informed consent obtained from each participant. This hospital-based cross-sectional study was done from May 2017 to April 2018. Study population consisted of patients attending the dermatology OPD and having lesions clinically suggestive of contact dermatitis and there were 268 such patients. Patients attending the OPD were divided into urban and rural as per their address. Data analysis was done using suitable, standard, and appropriate statistical methods. RESULTS: < 0.05). CONCLUSIONS: Contact dermatitis prevalence and patient profile in certain factors showed a statistically significant difference between urban and rural patients.
Contact Dermatitis · 2011 · 5 citations · open access
Animal Models of Contact Dermatitis
AbstractContact dermatitis is an inflammatory disease of the skin resulting from direct contact with foreign substances. Understanding the immunological processes that cause the disease is therefore essential for the development of new therapeutic strategies. Murine models of chemically induced dermatitis have played an essential role in our understanding of the pathophysiology of contact dermatitis, unraveling the role played by inflammatory mediators and identifying potential targets for therapeutic interventions. In the present chapter we review data obtained in animal models of allergic and irritant contact dermatitis and provide basic protocols to reliably induce contact dermatitis. A major intent of this chapter is to highlight the respective role of innate and adaptive immune cells in contact dermatitis pathogenesis as revealed by murine studies. Through genetic ablation of single molecules or depletion of specific cell subsets, murine studies provide novel insight on the role of different components of the immune system in the development of contact dermatitis. We review the experimental evidence revealing the role of different T cell subsets in contact dermatitis development, focusing our attention on mechanisms responsible for maintenance or disruption of immune-tolerance. Our analyses will focus on molecular pathways which are promising candidates as targets of future biological therapies.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
