DeCure for Combined immunodeficiency with skin granulomas
DeCure's autonomous Dermatology AI scientist is researching a drug-repurposing hypothesis for combined immunodeficiency with skin granulomas — screening already-approved drugs against its 3-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleCombined immunodeficiency with skin granulomas maps to a 3-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for combined immunodeficiency with skin granulomas is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
recombination activating 2 (RAG2) — RAG2 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 8T4R · 1.2 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
Cutaneous sarcoid-like granulomas have been described in patients with primary immunodeficiency, specifically common variable immunodeficiency and thymoma with hypogammaglobulinaemia. A 1994 report of two such patients states this is the first time these skin lesions have been recorded in primary immunodeficiency. The authors propose the granulomas may result from a combination of interleukin-2 deficiency and profound CD4 lymphopenia, drawing a parallel to the non-infectious papular eruption seen in HIV infection and suggesting a shared pathogenic mechanism.
A separate 1992 case describes a patient presenting with extensive disseminated granuloma annulare, an atypical variant of a granulomatous dermatosis, in whom underlying HIV disease was confirmed. The authors note that atypical variants of granuloma annulare have been suggested to associate with AIDS. A 2014 case report details a patient with undiagnosed common variable immunodeficiency who first presented with necrotizing and sarcoidal granulomas on the skin and synovial membrane, illustrating that granulomatous lesions can be the initial manifestation of immunodeficiency and make diagnosis difficult.
No drug treatment is mentioned in any of these abstracts. No data on survival, response rates, or sample sizes beyond single patients or two-patient reports are provided. The evidence is limited to case descriptions linking granulomatous skin lesions to underlying immune defects, without any interventional data.
What is missing is any clinical trial testing a drug for this condition, any systematic patient series with treatment outcomes, and any validated stratification of patients by specific immune defect. Without these, no drug can be assessed for efficacy in combined immunodeficiency with skin granulomas.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
British Journal of Dermatology · 1994 · 42 citations
Cutaneous sarcoid-like granulomas in primary immunodeficiency disorders
AbstractWe report the occurrence of cutaneous sarcoid-like granulomas in one patient with common variable immunodeficiency and another with 'thymoma and hypogammaglobulinaemia'. To our knowledge, this is the first time that such skin lesions have been described in patients with primary immunodeficiency. These granulomas may be attributed to a combination of interleukin-2 deficiency and a profound CD4 lymphopenia. The lesions are similar to the non-infectious 'papular eruption' associated with human immunodeficiency virus infection, and might reflect a common pathogenic mechanism.
Clinical and Experimental Dermatology · 1992 · 40 citations
Disseminated granuloma annulare as a presentation of acquired immunodeficiency syndrome (AIDS)
AbstractLocalized granuloma annulare is the commonest form of a granulomatous dermatosis characterized by flesh coloured or violaceous papules often arranged in rings. Several rare atypical variants are also reported including disseminated or generalized, subcutaneous and perforating types. There is a predilection for females and a documented association with diabetes mellitus in some cases. Recently it has been suggested that atypical variants of granuloma annulare might be associated with the acquired immunodeficiency syndrome (AIDS). We describe a patient presenting with extensive generalized granuloma annulare in whom an underlying diagnosis of Human Immunodeficiency Virus (HIV) disease was confirmed.
Clinical and Experimental Dermatology · 2014 · 5 citations
Necrotizing and sarcoidal granulomas in the skin and synovial membrane, associated with common variable immunodeficiency
AbstractCommon variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia, T-cell abnormalities and recurrent bacterial infections. Patients with CVID can present granulomatous lesions on both the skin and other organs. When these lesions are the first sign of the disease, the diagnosis can be very challenging. We report the case of a patient with undiagnosed CVID, who presented with necrotizing and sarcoidal granulomas on the skin and synovial membrane as the first appearance of immunodeficiency.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
