DeCure's autonomous Cardio AI scientist is researching a drug-repurposing hypothesis for cerebral artery occlusion — screening already-approved drugs against its 4-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleCerebral artery occlusion maps to a 4-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for cerebral artery occlusion is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
CCR4-NOT transcription complex subunit 7 (CNOT7) — CNOT7 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 4GMJ · 2.7 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
A 1994 review of interventional neurovascular techniques reported that cerebral percutaneous transluminal angioplasty for high-grade stenosis of innominate, subclavian, carotid, vertebral, and intracranial vessels had a success rate greater than 90% with less than 10% morbidity. For severe angiographic vasospasm due to subarachnoid haemorrhage, transluminal angioplasty and local infusion of antispasmodic drugs produced neurological improvement in 60–80% of patients. Local intraarterial fibrinolysis for acute thromboembolic occlusion was described as beneficial in preliminary studies, with early revascularisation associated with improved neurological outcome. The review noted that these procedures were under investigation and that controlled clinical trial results were not yet available.
A 2023 systematic review and meta-analysis comparing endovascular therapy with best medical management for isolated posterior cerebral artery occlusion is referenced only by its supplemental material, which provides no numerical results. A separate 2023 case series of mechanical thrombectomy for patients with occlusions in both the anterior cerebral artery and middle cerebral artery found that among 341 thrombectomies performed across ten institutions, only seven patients had such dual occlusions. The median time from onset to imaging was 106 minutes, imaging to puncture 60 minutes, and puncture to recanalisation 74 minutes. Only one of the seven patients (14%) had a modified Rankin Scale score of 0–2 at 90 days, leading the authors to conclude that comorbid anterior cerebral artery occlusion may worsen outcome in middle cerebral artery occlusion.
A 1997 abstract states that for patients with posterior circulation stroke due to basilar or vertebral artery occlusion who present more than six hours after symptom onset and deteriorate after drug treatment, multimodal recanalisation may be feasible and safe, but provides no patient numbers or outcome rates. A 2023 case report describes successful endovascular treatment of a tandem occlusion of the internal carotid artery and an ipsilateral fetal posterior cerebral artery, with excellent neurological and functional outcome, but notes that further investigations are needed to determine the best treatment.
A 2018 case report describes a 55-year-old man with chronic myeloid leukaemia who developed cerebral infarction and severe intracranial artery stenosis during nilotinib treatment. Vessel wall magnetic resonance imaging showed diffuse concentric vessel wall thickening, unlike ordinary atherosclerosis. He underwent superficial temporal artery to middle cerebral artery bypass and was successfully treated without recurrence. The report suggests that surgical revascularisation may improve prognosis in nilotinib-associated cerebrovascular disease causing severe stenosis or occlusion of the main trunk of cerebral arteries.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
American Journal of Roentgenology · 1994 · 39 citations
Interventional neurovascular techniques for cerebral revascularization in the treatment of stroke.
AbstractRecent advances in interventional neurovascular radiology have altered the management of cerebrovascular diseases by providing alternative treatments in three areas. (1) Cerebral percutaneous transluminal angioplasty is being used more often as an alternative to surgical endarterectomy or bypass grafting for patients with high-grade vascular stenosis of the innominate, subclavian, carotid, vertebral, and intracranial blood vessels. To date, the success rate has been greater than 90%, with less than 10% morbidity. (2) Transluminal angioplasty and local infusion of antispasmodic drugs are being used to treat patients with severe angiographic vasospasm unresponsive to conventional medical therapy. Intracranial arterial vasospasm due to subarachnoid hemorrhage has remained a leading cause of delayed morbidity and mortality. Neurologic improvement, defined as improvement in the Hunt and Hess neurologic grading scale, has been shown in 60-80% of the patients so treated. (3) Local intraarterial fibrinolysis has been beneficial for patients with acute thromboembolic occlusion in both intracranial arteries and the cerebral dural sinuses. Preliminary studies indicate that early revascularization is associated with improved neurologic outcome. This review delineates the current state of the art in interventional neurovascular techniques for treating patients with stroke in evolution and patients with signs and symptoms of impending stroke due to vascular stenosis or occlusion. These techniques for cerebral revascularization are under investigation as potential life-saving therapy when conventional medical or surgical treatment has failed. As more experience is gained, the results of controlled clinical trials become available, and technical improvements evolve, these procedures will decrease the morbidity and mortality associated with strokes.
Molecular and Clinical Oncology · 2018 · 17 citations · open access
Vessel wall magnetic resonance imaging findings and surgical treatment in nilotinib‑associated cerebrovascular disease: A case report
AbstractNilotinib, a second-generation tyrosine kinase inhibitor, is considered as one of the most effective drugs for the treatment of chronic myeloid leukemia (CML); however, the use of nilotinib has been reported to be associated with vascular adverse events, such as peripheral arterial occlusive disease and ischemic heart disease. Moreover, there are few reports on cerebral vascular disease associated with nilotinib use. We herein describe the case of a 55-year-old male patient with CML, who presented with cerebral infarction and severe cerebrovascular stenosis that developed during nilotinib treatment. The patient was diagnosed with cerebral infarction and severe stenosis of the intracranial arteries associated with nilotinib use. Vessel wall magnetic resonance imaging (VW-MRI) revealed diffuse concentric thickening of the vessel wall, unlike ordinary patterns of atherosclerosis. The patient underwent direct revascularization (superficial temporal artery to middle cerebral artery bypass) and was successfully treated without recurrence. Based on this rare case, VW-MRI may be used to detect the morphological changes of the intracranial arteries that are associated with nilotinib use. Moreover, surgical revascularization may improve the prognosis of nilotinib-associated cerebrovascular diseases, such as severe stenosis or occlusion of the main trunk of the cerebral arteries, that cause brain ischemia.
Journal of Neuroendovascular Therapy · 2023 · 0 citations · open access
Mechanical Thrombectomy for Patients with Occlusions in Both the Anterior Cerebral Artery and Middle Cerebral Artery: Case Series and Review of the Literature
AbstractObjective: Most large-vessel occlusions (LVOs) amenable to acute recanalization occur in the internal carotid or middle cerebral artery. However, few LVOs with a multivessel disease can be difficult to treat. This study aimed to determine the outcomes of mechanical thrombectomy in patients with both anterior and middle cerebral artery occlusions. Methods: We retrospectively collected data for patients who had undergone mechanical thrombectomy since January 2016 at Fukushima Medical University and its affiliated institutions (10 institutions). Patients with occluded vessels in the anterior and middle cerebral arteries were selected, and patient background, treatment course, and outcomes were reviewed. Results: A total of 341 mechanical thrombectomies were performed during the study period. Seven patients had occlusions involving both anterior and middle cerebral arteries. In these seven patients, the median time from onset to imaging, imaging to puncture, and puncture to recanalization was 106, 60, and 74 min, respectively. Only one patient (14%) had a modified Rankin Scale of 0-2 at 90 days. Conclusion: Comorbid anterior cerebral artery occlusion may worsen the outcome of patients with middle cerebral artery occlusion.
INDIGO (University of Illinois at Chicago) · 2023 · 0 citations · open access
sj-pdf-1-eso-10.1177_23969873231201715 – Supplemental material for Endovascular therapy versus best medical management for isolated posterior cerebral artery occlusion: A systematic review and meta-analysis
AbstractSupplemental material, sj-pdf-1-eso-10.1177_23969873231201715 for Endovascular therapy versus best medical management for isolated posterior cerebral artery occlusion: A systematic review and meta-analysis by Ahmed Alkhiri, Aser F Alamri, Abdullah R Alharbi, Ahmed A Almaghrabi, Nayef Alansari, Abdulelah A Niaz, Basil A Alghamdi, Amrou Sarraj, Adel Alhazzani and Fahad S Al-Ajlan in European Stroke Journal
AbstractFor patients with posterior circulation stroke due to basilar artery or vertebral artery occlusion who present to the hospital 6 h after symptom onset and who exhibit deterioration of symptoms after drug treatment, multimodal recanalization of the occluded artery may be a feasible and safe therapy.
Revista de Neurología · 2023 · 0 citations · open access
Ictus isquémico agudo por oclusión en tándem de la arteria carótida interna y la arteria cerebral posterior fetal: tratamiento endovascular
AbstractINTRODUCTION: When the posterior cerebral artery arises from the internal carotid artery with an absent P1 segment, it is called fetal posterior cerebral artery (FPCA). It is unclear whether FPCA increases the risk of acute ischemic stroke, and the endovascular treatment of acute ischemic stroke due to acute occlusion of FPCA is not well established. CASE REPORT: We report a case of acute ischemic stroke due to tandem occlusion of internal carotid artery and ipsilateral fetal posterior cerebral artery treated successfully with acute stenting of proximal lesion and mechanical thrombectomy of distal lesion with excellent neurological and functional outcomes. CONCLUSION: Although further investigations are needed to determine the best treatment of these patients, endovascular treatment of fetal posterior cerebral artery occlusion is feasible.
Sage Journals Data · 2023 · 0 citations · open access
sj-pdf-2-eso-10.1177_23969873231201715 – Supplemental material for Endovascular therapy versus best medical management for isolated posterior cerebral artery occlusion: A systematic review and meta-analysis
AbstractSupplemental material, sj-pdf-2-eso-10.1177_23969873231201715 for Endovascular therapy versus best medical management for isolated posterior cerebral artery occlusion: A systematic review and meta-analysis by Ahmed Alkhiri, Aser F Alamri, Abdullah R Alharbi, Ahmed A Almaghrabi, Nayef Alansari, Abdulelah A Niaz, Basil A Alghamdi, Amrou Sarraj, Adel Alhazzani and Fahad S Al-Ajlan in European Stroke Journal
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
