DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Cavernous Hemangioma — screening already-approved drugs against its 5-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleCavernous Hemangioma maps to a 5-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for cavernous hemangioma is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
KRIT1 ankyrin repeat containing (KRIT1) — KRIT1 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet gnpdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 4HDO · 1.67 Å · ligand PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER (GNP). Experimental structure, not a prediction.
What the evidence adds up to
A 2001 case report describes an intrasellar cavernous hemangioma that on neuroimages mimicked a nonfunctioning pituitary macroadenoma in a patient with a known orbital hemangioma. The authors note such lesions can grow extraaxially within the dural sinuses, particularly the cavernous sinus, and present like tumours. No treatment or outcome data are given; the report only urges better understanding of neuroimaging, clinical, and anatomical features to prevent management difficulties.
A 2022 case report describes a 20-year-old man with an ileal cavernous hemangioma causing chronic haemorrhage. His presenting haemoglobin was 3.4 g/dL (normal range 12–16 g/dL). Gastroscopy, colonoscopy, and peroral double-balloon enteroscopy showed no bleeding; transanal double-balloon enteroscopy detected a lesion about 340 cm proximal to the ileocecal valve. Exploratory laparoscopy and resection were performed, and after operation the patient had no melena. Pathological examination identified the neoplasm as an ileal cavernous hemangioma. The report is a single case, provides no long-term follow-up, and offers no controlled data on recurrence or survival.
A 2019 first-person account describes an orbital cavernous hemangioma that went undiagnosed after two exploratory surgeries. An MRI ultimately confirmed the condition. The author recommends patients do research, get second or third opinions, and ask about diagnostic tools such as MRI. No treatment outcomes, response rates, or survival data are provided.
No randomised trial, no controlled comparison of treatments, and no prospective cohort exists for cavernous hemangioma at any anatomical site. What is missing is a systematic diagnostic pathway validated against surgical or imaging confirmation, any trial of medical therapy, and any data on natural history stratified by location and size.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Journal of neurosurgery · 2001 · 23 citations
Intrasellar cavernous hemangioma
AbstractThe authors present a rare entity, an intrasellar cavernous hemangioma that on neuroimages mimicked a nonfunctioning pituitary macroadenoma in a patient with a known orbital hemangioma. Such lesions can grow extraaxially within the dural sinuses, particularly the cavernous sinus, and present like tumors. A better understanding of the neuroimaging. clinical, and anatomical features of these lesions may prevent difficulties in management.
World Journal of Clinical Cases · 2022 · 4 citations · open access
Cavernous hemangioma of the ileum in a young man: A case report and review of literature
AbstractBACKGROUND: Small intestinal cavernous hemangioma is a rare disease, especially in the ileum. It is difficult to accurately diagnose due to its hidden location and nonspecific clinical symptoms. Here, we reported a case of ileal cavernous hemangioma with chronic hemorrhage in a 20-year-old man and review the literature to gain a better understanding of this disease. CASE SUMMARY: The patient complained of intermittent melena and hematochezia for > 3 mo. The lowest hemoglobin level revealed by laboratory testing was 3.4 g/dL (normal range: 12-16 g/dL). However, the gastroscopy, colonoscopy and peroral double-balloon enteroscopy (DBE) showed no signs of bleeding. The transanal DBE detected a lesion at about 340 cm proximal to the ileocecal valve. Thus, we performed an exploratory laparoscopy and the lesion was resected. After the operation, the patient had no melena. Finally, the pathological examination identified the neoplasm as an ileal cavernous hemangioma, thereby resulting in gastrointestinal hemorrhage. CONCLUSION: This report might improve the diagnosis and treatment of ileal cavernous hemangioma.
The Journal of Health Design · 2019 · 0 citations · open access
How cavernous hemangioma went undiagnosed and lessons learned
AbstractA barely noticeable lump on the bottom medial part of my right eyelid went undiagnosed after two exploratory surgeries. Additional exploratory surgeries were recommended in subsequent consults with different ophthalmologists without anyone suggesting diagnostic tools (eg, MRI). An MRI ultimately confirmed a common condition called an orbital cavernous hemangioma. Patients can contribute to their patient experience by doing research, being informed, asking questions, and getting a second, even third, opinion, if necessary.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
