DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for capillary leak syndrome — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleCapillary leak syndrome maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for capillary leak syndrome is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
talin 1 (TLN1) — TLN1 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 6R9T · 6.2 Å · ligand none (apo structure). Experimental structure, not a prediction.
What the evidence adds up to
A 2003 review of capillary leak in critically ill patients states that attempts to prevent or treat the process remain largely unsuccessful, and that resuscitation is more often symptomatic than therapeutic. The review notes that understanding of capillary leak syndrome is fragmented and weighted toward specific mediators, and that the mechanism by which extensive edema resolves continues to be the subject of speculation rather than study.
A 2014 case report describes a 54-year-old man with idiopathic systemic capillary leak syndrome who developed abdominal and four-limb compartment syndrome. He was treated with fasciotomies and medical treatment including terbutaline, theophylline, and corticosteroids, and after 60 days was dismissed from the clinic able to return to his previous occupation and athletic activity. The authors state this is the first report of such a case, and that early diagnosis and interdisciplinary treatment can lead to a good clinical outcome.
A 2019 review of neonatal capillary leak syndrome states that clinical treatment is difficult, that there is no uniform diagnostic criteria, and that treatment is empiric with no specific treatment. The review identifies primary disease treatment and fluid management as the critical parts of treatment.
No randomised trial data, no validated biomarker for patient selection, and no funding for a controlled study of any drug regimen are reported in these abstracts. The 2014 case report describes a single patient treated with a combination of drugs, but no controlled evidence supports any of those agents.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Critical Care Medicine · 2003 · 90 citations
Vessel injury and capillary leak
AbstractOBJECTIVE: To understand the mechanism of pathologic capillary leak in the critically ill patient. DESIGN: Review of normal and altered physiology of the microvasculature. Review of recent literature describing pathogenesis, mediators, and interventions influencing capillary leak and microvascular repair. SETTING: In vitro and in vivo studies, the latter including animal and human subjects. MEASUREMENTS AND MAIN RESULTS: Capillary leak with resultant edema develops in the critical care setting on the basis of perturbations in Starling's equation, primarily as a result of increased capillary permeability to larger molecules. This process is most likely fueled by inflammatory mediators or mechanical stress. Attempts to prevent or treat this process remain largely unsuccessful; resuscitation is more often symptomatic than therapeutic. Models of microvascular repair focus on discrete injury and may not be applicable to the recovery of capillary damage secondary to a systemic leak CONCLUSIONS: Our understanding of capillary leak syndrome remains fragmented and weighted toward specific mediators contributing to the leak. The implications of extensive edema and the mechanism by which it resolves continue to be the subject of speculation rather than study.
Journal of Medical Case Reports · 2014 · 12 citations · open access
Systemic capillary leak syndrome associated with a rare abdominal and four-limb compartment syndrome: a case report
AbstractINTRODUCTION: Systemic capillary leak syndrome is a rare and life threatening disease characterized by periodic episodes of hypovolemic shock due to leakage of plasma from the intravascular to the extravascular space. It is associated with hemoconcentration, hypoalbuminemia, and generalized edema. We report the case of a patient with idiopathic systemic capillary leak syndrome who developed an unexpected and potentially fatal abdominal and four-limb compartment syndrome. This was successfully treated with fasciotomies and medical treatment including terbutaline, theophylline, and corticosteroids. To the best of our knowledge this is the first report of this kind in the literature. CASE PRESENTATION: A previously healthy 54-year-old Caucasian man presented to the emergency department of our internal medicine ward with a medical history of aggravation of general health related to dizziness, weight gain, and two syncopal attacks. Due to a massive emission of fluids and proteins from the intravascular to the extracellular compartments, he developed compartment syndromes in his upper and lower limbs and the abdominal compartment. The abdomen and all four limbs required decompression by a fasciotomy of both forearms, both thighs, both lower legs, and the abdomen within 24 hours after admission. After 60 days of treatment he was dismissed from the clinic. He was able to return to his previous occupation and reached the same level of athletic activity as before the illness. CONCLUSIONS: Systemic capillary leak syndrome is a very rare disease that can lead to a fatal clinical outcome. It is important to be aware of the fatal complications that can be caused by this disease. Despite the fact that systemic capillary leak syndrome represents a very rare disease it is still important to be aware of life threatening complications, like compartment syndromes, which need surgical intervention. However, early diagnosis and interdisciplinary treatment can lead to a good clinical outcome.
AbstractCapillary leak syndrome(CLS)is a group of clinical syndromes which caused by various causes of capillary endothelial damage, increased vascular permeability, resulting in a large amount of plasma protein infiltration into the interstitial space.It is one of the common critical cases in Neonatal Intensive Care Unit.As the complicated pathogenesis, blurred clinical stage and often neglected due to other complications, clinical treatment of CLS is difficult.Currently, there is no uniform diagnostic criteria, and the diagnosis is mainly based on clinical manifestation and laboratory examination.The treatment of it is empiric but no specific treatment.Primary disease treatment and fluid management are the critical parts of the treatment of CLS.Now, the etiology, pathogenesis, clinical diagnosis and treatment of the disease were explained combined with the domestic and foreign literature and clinical diagnosis and treatment practices, which aims to improve clinicians′ understanding of the disease and the level of clinical diagnosis and treatment.
Key words:
Capillary leak syndrome; Diagnosis; Treatment; Infant, newborn; Clinical practice
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
