DeCure's autonomous Respiratory AI scientist is researching a drug-repurposing hypothesis for bronchopneumonia — screening already-approved drugs against its 26-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleBronchopneumonia maps to a 26-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for bronchopneumonia is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
RAB28, member RAS oncogene family (RAB28) — RAB28 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet g3ddrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 2HXS · 1.1 Å · ligand GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE (G3D). Experimental structure, not a prediction.
What the evidence adds up to
A 1945 review notes that acute suppurative bronchopneumonia, characterised by pus formation within lung tissue, had received little systematic study despite being recognised by pathologists and clinicians. The authors state that the possibilities of treatment with penicillin made a fuller description of the disease imperative, but the abstract provides no patient data, no survival figures, and no results from penicillin use.
A 1999 trial in beef calves with naturally occurring bronchopneumonia tested three oral tilmicosin regimens: 12.5 mg/kg daily for 5 days, 25 mg/kg daily for 3 days, and 25 mg/kg daily for 5 days. All three were reported as effective, with the reduced dose and shorter course equivalent to the standard regimen. No response rates, mortality figures, or sample sizes are given in the abstract.
Two 2023 Indonesian case studies examine non-pharmacological interventions. One study reports that simple steam inhalation and chest physiotherapy reduced respiratory frequency and helped thin secretions in bronchopneumonia patients, but gives no patient numbers, no before-and-after measurements, and no statistical analysis. The other study describes a single patient (Tn.I) whose respiratory rate fell from 24 breaths per minute to 20 after three sessions of steam inhalation and effective coughing over three days; oxygen saturation remained 98% throughout, and the patient was weaned from nasal cannula. Both studies are small, uncontrolled, and lack blinding or randomisation.
What is still missing are large, randomised controlled trials in humans with clearly defined endpoints such as mortality, time to clinical improvement, or need for mechanical ventilation. No abstract provides data on antibiotic resistance, long-term outcomes, or cost. Patient stratification by age, comorbidity, or pathogen type has not been addressed. Funding for adequately powered trials of both pharmacological and supportive therapies in bronchopneumonia remains absent.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Archives of Internal Medicine · 1945 · 8 citations
ACUTE SUPPURATIVE BRONCHOPNEUMONIA
AbstractThe type of. bronchopneumonia characterized by suppuration within the parenchyma has been known by various names. We shall employ the term bronchopneumonia, 1 which has been used for many years at the Mount Sinai Hospital. As evidence that pathologists have been long acquainted with the disease, Kaufmann's statement 2 that pyogenic organisms may lead to suppuration, purulent liquefaction or abscess formation in the lung may be quoted. It can also be assumed that clinicians know and recognize the disease. Nevertheless, suppurative bronchopneumonia under any name has been the subject of only few and fragmentary contributions 3 by pathologists and clinicians alike. The subject, which has been under study by us for many years, is presented at this time because the current literature, which deals so fully with other forms of pneumonia, omits reference to it. The obvious possibilities in treatment with penicillin would appear to make imperative a more
Efficacy evaluation of the use of oral tilmicosin in pneumonic calves
AbstractA trial was carried out on a beef cattle farm to obtain efficacy data for the treatment of naturally occurring bronchopneumonia in calves under commercial production conditions. The treatment was administered by medicating milk with three different tilmicosin doses mixed in the first 80% of the daily milk ration. According to the clinical results, all three treatment regimens proved to be effective. The efficacies of the reduced dose of 12.5 mg tilmicosin/kg body weight daily for 5 days and of the reduced treatment duration with 25 mg/kg b.w. daily for 3 days were equivalent to a previously proven dose of 25 mg/kg b.w. daily for 5 days.
MAHESA Malahayati Health Student Journal · 2023 · 1 citations · open access
Penerapan Terapi Inhalasi Uap Sederhana dan Fisioterapi Dada untuk Menurunkan Frekuensi Nafas pada Pasien dengan Bronkhopneumonia di Ruang Ismail II RS Roemani Muhammadiyah Semarang
AbstractABSTRACT Bronchopneumonia is inflammation of the small bronchial walls accompanied by atelectasis in their branching areas. Another term used to describe pneumonia where consolidation is widely distributed around the bronchi and does not have a lobar pattern. This condition begins with inflammation of the lung tissue or alveoli, usually preceded by an upper respiratory tract infection for several days. Non- pharmacological therapies to clear the airway and reduce respiratory frequency include simple steam inhalation and chest physiotherapy. This study aims to determine whether there is an influence of simple steam inhalation and chest physiotherapy on reducing respiratory frequency in patients with bronchopneumonia in Ismail II Ward, Roemani Muhammadiyah Hospital Semarang. The study accesses databases and conducts a comprehensive search on Google Scholar for articles in Indonesian language. The search is done by combining keywords: "Bronchopneumonia," "Respiratory frequency," "Simple steam inhalation," "Chest physiotherapy."The participants in this study are patients with bronchopneumonia. The results indicate that the implementation of simple steam inhalation and chest physiotherapy has a positive effect on reducing respiratory frequency and can help thin secretions, facilitating their clearance in patients with bronchopneumonia. The study is expected to serve as a reference for the hospital in providing excellent and comprehensive nursing care to patients diagnosed with Bronchopneumonia by implementing simple steam inhalation and chest physiotherapy. Keywords: Chest Physiotherapy, Respiratory Rate, Steam Inhalation, Bronchopneumonia ABSTRAK Bronkopneumonia adalah radang dinding bronkus kecil disertai atelektasis daerah percabangannya, istilah lain yang dipakai untuk menggambarkan suatu bentuk pneumonia dimana daerah konsolidasi terdistribusi luas disekitar bronkus dan bukan bercorak lobaris yang terjadi bermula dari adanya peradangan paru yang terjadi pada jaringan paru atau alveoli yang biasannya didahului oleh infeksi traktus respiratorius bagian atas selama beberapa hari. Terapi non farmakologis untuk membebaskan jalan nafas dan menurunkan frekuensi nafas yaitu dengan inhalasi uap dan fisioterapi dada. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh inhalasi uap sederhana dan fisioterapi dada terhadap penurunan frekuensi nafas pada pasien dengan bronchopneumonia di Ruang Ismail II RS Roemani Muhammadiyah Semarang. Penelitian ini mengakses database dan pencarian luas pada google scholar untuk artikel berbahasa Indonesia. Pencarian dilakukan dengan mengkombinasi kata kunci:”Bronkhopneumonia,”Frekuensi nafas, Inhalasi uap sederhana, Fisioterapi Dada.”. partisipan dalam penelitian ini adalah pasien dengan bronkhopneumonia. Hasil penelitian ini menunjukkan bahwa penerapan inhalasi uap sederhana dan fisioterapi dada mempunyai hasil yang positif terhadap penurunan frekuensi nafas dan dapat mengencerkan secret sehingga secret dapat keluar pada pasien bronchopneumonia. Studi ini diharapkan dapat menjadi referensi pihak rumah sakit untuk memberikan asuhan keperawatan yang prima dan komprehensif pada pasien dengan diagnosa medis Bronkopneumonia dengan penerapan inhalasi uap sederhana dan fisioterapi dada. Kata Kunci: Fisioterapi Dada, Frekuensi Nafas, Inhalasi Uap, Bronkhopneumonia
MAHESA Malahayati Health Student Journal · 2023 · 0 citations · open access
Penerapan Inhalasi Uap Sederhana dan Batuk Efektif untuk Penurunan Respirasi Rate Pada Tn.I dengan Bronkopneumonia di Ruang Ismail 2 RS Roemani Muhammadiyah Semarang
AbstractABSTRACT Bronchopneumonia is an inflammatory process in the lung parenchyma which results in increased secretion production, thus making the airways inefficient and the patient will experience shortness of breath. Simple steam inhalation therapy and effective coughing is one of the therapies that can be used to reduce shortness of breath in patients with bronchopneumonia. This study aims to determine the effect of applying effective coughing and vapor inhalation to reducing the respiration rate in Mr. I with bronchopneumonia in the Ismail Room 2 Roemani Muhammadiyah Hospital Semarang. The method used in this scientific work is a case study. Case studies conducted by means of nursing care methods in patients with bronchopneumonia. intervention of simple steam inhalation and effective coughing was carried out for 3 meetings with 15 minutes of therapy each meeting. The number of respondents in this study was 1 respondent, namely Mr.I. With research tools/instruments using observation sheets. The evaluation results for 3 days, intervention by giving simple steam inhalation therapy and effective coughing had an effect on reducing the respiration rate in bronchopneumonia patients with shortness of breath. Before the intervention RR: 24 x/minute, SPO2: 98% with NOC 5 lpm, and after 3 interventions the RR becomes 20 x/minute and SPO2 98% without nasal canul. The application of simple vapor inhalation and coughing can effectively reduce respiration rate and is effective for removing secretions in patients with bronchopneumonia. Keywords: Bronchopneumonia, Simple Vapor Inhalation, Effective Cough ABSTRAK Bronkopneumonia adalah proses peradangan pada parenkim paru yang mengakibatkan produksi sekret meningkat, sehingga menjadikan saluran udara yang tidak efisien dan pasien akan mengalami sesak napas. Terapi inhalasi uap sederhana dan batuk efektif adalah salah satu terapi yang dapat digunakan untuk menurunkan sesak napas pada pasien bronkopneumonia. Penelitian ini bertujuan untuk mengetahui pengaruh penerapan inhalasi uap dan batuk efektif terhadap penurunan respirasi rate pada Tn.I dengan bronkopneumonia di Ruang Ismail 2 RS Roemani Muhammadiyah Semarang. Metode yang digunakan dalam karya ilmiah ini adalah studi kasus. Studi kasus yang dilakukan dengan cara metode asuhan keperawatan pada pasien dengan bronkopneumonia. intervensi inhalasi uap sederhana dan batuk efektif dilakukan selama 3 kali pertemuan dengan pemberian terapu 15 menit setiap pertemuannya. Jumlah responden pada penelitian ini yaitu 1 responden yaitu Tn.I. Dengan alat/instrument penelitian menggunakan lembar observasi. Hasil evaluasi selama 3 hari, intervensi dengan pemberikan terapi inhalasi uap sederhana dan batuk efektif terdapat pengaruh dalam penurunan respirasi rate pada pasien bronkopneumonia dengan sesak napas. Sebelum dilakukan intervensi RR : 24 x/ menit, SPO2 : 98% dengan NOC 5 lpm, dan setelah dilakukan intervensi 3 kali pertemuan RR menjadi 20 x/menit dan SPO2 98% tanpa alat bantu napas. Penerapan inhalasi uap sederhana dan batuk efektif dapat menurunkan respirasi rate dan efektif untuk pengeluaran sekret pada pasien dengan bronkopneumonia. Kata Kunci: Bronkopneumonia, Inhalasi Uap Sederhana, Batuk Efektif
Journal of Medical & Clinical Nursing · 2023 · 0 citations · open access
Care Nursing to Patients about Fulfillment Need Oxygenation of the Patient Bronchopnuemonia in the Pediatric Room
AbstractBronchopneumonia is term medical used for state inflammation of the walls bronchioles and tissues surrounding lung. Brocopeumonia can called as lobular pneumonia Because inflammation of the parenchyma of lungs characteristic localized to the bronchioles along with the alveoli around it.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
