DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for atrichia with papular lesions — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleAtrichia with papular lesions maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for atrichia with papular lesions is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
What the evidence adds up to
The 1961 paper by Loewenthal and Prakken is a historical case description of atrichia with papular lesions; its full text is behind a paywall and no specific patient numbers, treatments, or outcomes are extractable from the available metadata. The 1979 report describes a single 41-year-old Japanese male with extensive gastrointestinal polyposis (stomach, duodenum, jejunum, ileum, colon, rectum) alongside atrichia, pigmentation, and epidermal cysts. The authors state this case does not fit Peutz-Jeghers, Gardner’s, or Cronkhite-Canada syndromes, nor the previously described atrichia with papular lesions alone, and they label it as a new association. No treatment or follow-up is given.
The 2023 case series reports three children with congenital atrichia, normal teeth, nails, and sweat glands, and central nervous system associations: developmental delay, spastic quadriparesis, failure to thrive, myoclonic seizures, and attention deficit hyperactivity disorder. Two of the three children also had papular lesions. Parental nonconsanguinity was noted in all three. The authors state that genetic analysis and counselling about the permanence of the condition are the mainstays of management. No drug, intervention, or outcome data beyond the clinical description are provided.
Across all three reports, no treatment was tested or recommended. There are no controlled trials, no response rates, no survival data, and no evidence that any drug alters the course of atrichia with papular lesions or its associated systemic features. What is missing is any funded clinical trial, any attempt at drug repurposing, any biomarker or genetic stratification that might separate the different syndromic presentations, and any longitudinal outcome data beyond single-case or small-series descriptions.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Dermatologica · 2009 · 48 citations
Atrichia with Papular Lesions
AbstractResearch Articles| October 28 2009 Atrichia with Papular Lesions Subject Area: Dermatology , Immunology and Allergy L.J.A. Loewenthal; L.J.A. Loewenthal aJohannesburg, Search for other works by this author on: This Site PubMed Google Scholar J.R. Prakken J.R. Prakken bAmsterdam Search for other works by this author on: This Site PubMed Google Scholar Dermatologica (1961) 122 (2): 85–89. https://doi.org/10.1159/000255187 Article history Published Online: October 28 2009 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation L.J.A. Loewenthal, J.R. Prakken; Atrichia with Papular Lesions. Dermatologica 1 February 1961; 122 (2): 85–89. https://doi.org/10.1159/000255187 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsDermatology Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1961Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
ATRICHIA WITH PAPULAR LESIONS ASSOCIATED WITH GASTROINTESTINAL POLYPOSIS
AbstractABSTRACT A 41‐year‐old Japanese male presented extensive polyposis involving the stomach, deodenum, jejunum, ileum, colon and the rectum; atrichia, pigmentation and epidermal cysts. This case does not fit any of the known syndromes, including Peutz‐Jeghers syndrome, Gardner's syndrome, Cronkhite‐Canada syndrome and atrichia with papular lesions. We diagnosed it as atrichia with papular lesions associated with gastrointestinal polyposis.
International Journal of Trichology · 2023 · 0 citations · open access
Rare Association of Congenital Atrichia with Central Nervous System: A Report of Three Cases
AbstractCongenital atrichia a rare form of alopecia in children, presents with complete absence or sparse hair over the scalp and body, while the teeth, nails, and sweat glands are normal. Uncommonly, this hair abnormality can be associated with any systemic or cutaneous abnormalities. We report three cases of congenital atrichia with parental nonconsanguinity and central nervous associations such as developmental delay,spastic quadriparesis, failure to thrive, myoclonic seizures, and attention deficit hyperactivity disorder. The presence of papular lesions in two among the three children further supplemented our case report. Genetic analysis and counseling regarding the constancy of the condition will be the foremost important part of management.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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