DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Angiolipoma — screening already-approved drugs against its 3-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleAngiolipoma maps to a 3-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for angiolipoma is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
What the evidence adds up to
Angiolipoma is a benign tumour composed of mature fat cells and blood vessels, most often found in subcutaneous tissue. A 2005 case report describes a colonic angiolipoma diagnosed preoperatively by CT, abdominal echo, barium enema, and colonoscopy, with the diagnosis confirmed after surgery. An infiltrating variant, described in two young women in a 1986 review, can invade skeletal muscle and behave as a locally aggressive neoplasm, requiring recognition to guide appropriate therapy. An orbital angiolipoma, reported in 2019 as only the third such case in that location, had an excellent prognosis after full surgical excision. A 2015 case report notes that angiolipomas usually occur in the upper extremities, shoulder, and back, and are seldom found in the hands, face, or lower extremities; they often present as painful soft tissue masses or may compress neighbouring structures such as nerves.
Cytogenetic analysis of three short-term cultured angiolipomas in a 2018 study found that all three had abnormal karyotypes with loss or structural rearrangement of chromosome 13. One tumour had the karyotype 46,XY,-6,del(13)(q14),+mar; the second had 44~45,XY,t(1;10;15)(p21~22;q24;q24),-13; and the third was 43,XX,t(13;22;17)(q12;q13;q22~23). Fluorescence in situ hybridisation using an RB1 deletion probe showed heterozygous deletion in case 2 and homozygous deletion in case 3. The authors note that genetic information on angiolipomas is scarce and that, with one exception, all previously investigated tumours had normal karyotypes.
No drug treatment is mentioned in any of these abstracts. There are no data on response rates, survival, or any pharmacological intervention. What is missing is any clinical trial testing a drug for angiolipoma, any systematic study of medical therapy, and any patient stratification beyond anatomical location and histologic subtype. The genetic finding of consistent chromosome 13 involvement, including RB1 deletion, has not been linked to a treatment strategy.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
World Journal of Gastroenterology · 2005 · 22 citations · open access
Preoperative diagnosis of colonic angiolipoma: A case report
AbstractAngiolipoma, a common benign tumor mostly seen in the subcutaneous tissue, is a rare pathological condition in the gastrointestinal tract that is usually diagnosed postoperatively. In this case report, an angiolipoma was diagnosed preoperatively by imaging (including CT scans, abdominal echo, barium enema, and colonoscopy). This pathology was confirmed postoperatively. Computed tomography scan, abdominal echo, and barium enema images were presented.
Cancer Genomics & Proteomics · 2018 · 17 citations · open access
Consistent Involvement of Chromosome 13 in Angiolipoma
AbstractBACKGROUND/AIM: Angiolipoma is a rare benign soft tissue tumor composed of mature adipocytes and blood vessels. Genetic information on angiolipomas is scarce. With the single exception of one tumor which carried a t(X;2)(p22;p12), all angiolipomas hitherto investigated cytogenetically had normal karyotypes. MATERIALS AND METHODS: G-banding chromosome analysis was performed on three short-term cultured angiolipomas. Fluorescence in situ hybridization (FISH) analysis using a commercially available RB1 deletion probe was also done. RESULTS: All three angiolipomas had abnormal karyotypes with loss or structural rearrangement of chromosome 13. The first tumor had the karyotype 46,XY,-6,del(13)(q14),+mar[cp5], the second had 44~45,XY,t(1;10;15)(p21~22;q24;q24),-13[cp5], and the third karyotype was 43,XX,t(13;22;17) (q12;q13; q22~23)[14]. FISH analysis showed heterozygous and homozygous deletion of the RB1 probe in case 2 and 3, respectively. FISH analysis failed in case 1. CONCLUSION: Chromosome 13 was consistently involved in all three angiolipomas.
The Journal of Dermatologic Surgery and Oncology · 1986 · 12 citations
Infiltrating Angiolipoma: Report of Two Cases and Review of the Literature
AbstractInfiltrating angiolipoma is an infrequent cutaneous tumor, with skeletal muscle infiltration that should be differentiated from the common encapsulated angiolipoma. We present two cases in young women, and review the literature. Infiltrating angiolipoma may be a locally aggressive neoplasm, which makes its clinicopathologic recognition and appropriate therapy important.
Ophthalmic Plastic and Reconstructive Surgery · 2019 · 2 citations
Angiolipoma of the Orbit
AbstractAngiolipoma is characteristically described as an encapsulated mass of mature adipose tissue containing clusters of small blood vessels. The authors have described an extremely rare case of angiolipoma of the orbit. This rare case is only the third reported in the orbit and should be readily recognized from other differential diagnoses. The patient had an excellent prognosis after full surgical excision.
Hand and microsurgery · 2015 · 1 citations · open access
Angiolipoma of index finger: A case report
AbstractAngiolipomas are usually found in the upper extremities, shoulder and back. They are seldom found in the hands, face and lower extremities. They usually occur as painful soft tissue masses or they may compress the neighboring structures (e.g. nerves) depending on the size and location. In this report we present an angiolipoma case located in the finger and discuss related recent cases described in the literature.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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