DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for angiokeratoma — screening already-approved drugs against its 2-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleAngiokeratoma maps to a 2-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for angiokeratoma is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
isocitrate dehydrogenase (NADP(+)) 1 (IDH1) — IDH1 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet ictdrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 6BKX · 1.65 Å · ligand ISOCITRIC ACID (ICT). Experimental structure, not a prediction.
What the evidence adds up to
Angiokeratoma is a cutaneous vascular disorder with several clinically distinct subtypes. One case report describes angiokeratoma corporis diffusum in a patient with no identifiable enzyme deficiency; the authors conclude this appears to be a distinct clinical entity with a benign course. Angiokeratoma circumscriptum is more common in women and is usually unassociated with systemic disease, presenting as hyperkeratotic papules and nodules most often unilaterally on the leg. Oral mucosal involvement, as in a reported solitary papular angiokeratoma of the tongue, is very rare in the localised forms. A separate report describes angiokeratoma of the gluteal region in an older patient, noting the lesions are 2 to 10 mm deep red to violet verrucous hyperkeratotic papules or plaques, with histology showing dilated blood vessels congested with erythrocytes in the subepidermis.
Two patients with angiokeratoma circumscriptum were treated with the argon laser and had no recurrences. No other treatments are reported in these abstracts. No drug therapy is mentioned for any subtype of angiokeratoma in any of the provided papers.
The abstracts do not provide data on sample sizes for any treatment beyond two patients, nor do they report survival or response rates. There is no information on randomised trials, patient stratification, or funding for controlled studies. What is missing is any trial design that could test a drug for this condition, and any evidence that a drug has been used or proposed.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Archives of Dermatology · 2006 · 36 citations
Angiokeratoma Corporis Diffusum in a Patient With No Recognizable Enzyme Abnormalities
AbstractBACKGROUND: Angiokeratoma corporis diffusum is a clinical variant of angiokeratoma that is typically associated with an enzyme deficiency in the metabolism of glycoprotein, most notably Fabry disease, resulting in many other systemic manifestations. OBSERVATIONS: We report a case of angiokeratoma corporis diffusum that did not have an identifiable enzyme deficiency. A review of the literature revealed few similar cases. CONCLUSION: Angiokeratoma corporis diffusum without recognizable enzyme deficiencies appears to be a distinct clinical entity with a benign course.
AbstractAngiokeratoma circumscriptum is one of five diseases in the group of angiokeratomas. It is more common in women and is usually unassociated with systemic disease. The lesions are hyperkeratotic papules and nodules occurring most frequently unilaterally on the leg. Its relationship of the other angiomas is discussed and an unusual case on the arm of a Negro man is presented.
Journal of Oral Pathology and Medicine · 2006 · 23 citations · open access
Solitary angiokeratoma of the tongue
AbstractAngiokeratoma is a rare, cutaneous vascular disorder that can occur in several clinically distinct conditions. It usually presents as multiple, red to blue or black, asymptomatic papules on the skin. Oral mucosal involvement is common in the systemic form, but very rare in the localized forms of angiokeratomas. We report the second case of a solitary papular angiokeratoma of the oral cavity.
Angiokeratoma Circumscriptum: Successful Treatment with the Argon Laser
AbstractThis article describes 2 patients with angiokeratoma circumscriptum for whom the argon laser proved to be a highly successful means of treatment. Both patients had no recurrences of the lesions. Also included is an updated and comprehensive review of the various types of angiokeratoma.
European Journal of Dermatology · 2017 · 0 citations
Angiokeratoma of the gluteal region in old age
AbstractAngiokeratoma (AK) is defined as a group of diseases, characterised by hyperkeratosis and dilated vessels in the upper dermis [1, 2]. Clinically, it presents with 2∼10-mm deep red to violet verrucous hyperkeratotic papules or plaques, and is classified into five subtypes according to pathophysiology and clinical features [1, 3, 4]. Histologically, it is characterised by one or more dilated blood vessels, congested with erythrocytes in the subepidermis [2, 5]. Other typical histological findings [...]
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
