DeCure's autonomous Psychiatry AI scientist is researching a drug-repurposing hypothesis for alcoholic gastritis — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleAlcoholic gastritis maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for alcoholic gastritis is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Korean Journal of Gastroenterology · 2018 · 4 citations · open access
Combined Extracts of <i>Artemisia</i> and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27
AbstractBackground/Aims: -associated gastric diseases, it was hypothesized that MPGT can offer protection against alcoholic gastritis. Methods: Ethanol was administered to induce gastric damage in Wistar rats, which had been pretreated with various doses of MPGT, to measure the rescuing action of a MPGT pretreatment against ethanol-induced gastric damage. In addition, the molecular mechanisms for the preventive effects were examined. Results: The MPGT pretreatment (100, 300, and 500 mg/kg) alleviated the ethanol-induced gastric damage, which was evidenced by the significant decrease in calcium-dependent phospholipase A2, MAPKs, and NF-κB levels compared to ethanol alone. Furthermore, the MPGT pretreatment preserved 15-prostaglandin dehydrogenase, whereas cyclooxygenase-2 was decreased significantly. All of these biochemical changes led to the significant alleviation of alcohol-associated gastric mucosal damage. Ethanol significantly increased the TUNEL positivity in the stomach, but MPGT decreased the apoptotic index significantly, which was associated with significantly lower pathological scores of ethanol-induced mucosal ulcerations. The significant protective changes observed alcoholic gastritis with MPGT were related to the increased expression of cytoprotective genes, such as heat-shock protein (HSP)27, HSP60, and PDGF. Conclusions: The efficient anti-inflammatory, anti-apoptotic, and regenerative actions of MPGT make it a potential nutrient phytoceutical to rescue the stomach from alcoholic gastritis.
AbstractGastritis is inflammation of the gastric mucosa. Alcohol ingestion may lead to an acute hemorrhagic or erosive gastritis through direct irritation of the gastric mucosa. Alcohol also leads to increased gastrin production and decreased pepsin secretion,which can cause gastric irritation. Endoscopy performed on healthy adults after direct ingestion of alcohol shows gastric hyperemia and erosions. Although alcohol-related gastritis most often is asymptomatic, it also may present with epigastric or upper abdominal pain, nausea, vomiting, and massive or occult gastrointestinal bleeding. In adults, alcohol use is a common cause of erosive gastritis, but nonsteroidal anti-inflammatory drug use is the most common cause. The incidence of alcoholic gastritis has not been identified in children and adolescents.Chronic antral inflammation frequently is observed in adult alcoholics. However, it is not clear whether this condition is a result of alcohol use, Helicobacter pylori, or their interaction. One study examined alcoholic patients who had gastritis after abstinence and then compared treatment for H pylori with antacid therapy. Neither abstinence from alcohol alone nor antacids was successful in improving gastritis. However, eradication of the H pylori cleared the gastritis. Ongoing animal studies also seem to confirm the presence of damaging interactions between H pylori and alcohol.Gastritis is neither common nor extensively studied in adolescents. As in adults, H pylori has been shown to be a causative agent, when present, in ulcer disease and gastritis in children and adolescents. Similarly, agents shown to be toxic in adults (such as alcohol) are at least as toxic in adolescents and children. Identification and treatment of alcoholic gastritis is important for several reasons: 1) chronic gastritis and ulcer disease increase future cancer risk; 2) gastritis can lead to life-threatening gastrointestinal bleeding; and, perhaps most important for adolescents, 3) identification of alcohol use should lead to interventions to decrease the morbidity and mortality associated with alcohol use and abuse.Alcohol use is a major problem among youth. Average age for first time use is 11.9 years for males and 12.7 years for females. Recent heavy drinking (defined as five or more drinks in a row in the past 2 weeks) has been reported by 15% of eighth graders, 24% of tenth graders, and 40% of college students. Parents often underestimate whether their children drink alcohol. Additionally,the physical indicators of alcohol or drug abuse seen in adults often are not seen in children; behavioral changes are more common indicators in youth.With the high prevalence of alcohol use among adolescents, it is important to question all adolescent patients about it. Current preventive services guidelines for adolescents recommend annual screening for alcohol use and counseling on its dangers, with a special emphasis on drinking and driving. Systematic screening about alcohol use at health super-vision visits provides an important opportunity to educate about and help prevent adolescent substance abuse. Special care should be taken to ask about alcohol use when adolescents present with abdominal symptoms, whether acute or chronic. Although not the most frequent cause of abdominal symptoms or of gastritis in adults or children, alcohol-related gastritis will not resolve until the offending agent is removed.Asking adolescents who have symptoms of gastritis about alcohol use is critical. Understanding the cause of the gastritis provides an opportunity to address the root of the problem—alcohol. Among adolescents, identification of alcohol use and alcohol-related morbidity and counseling on healthy behavior may influence lifelong health practices. This diagnosis can provide a window of opportunity.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
