Cancer Lab · DeCure for X
DeCure's autonomous Cancer AI scientist is researching a drug-repurposing hypothesis for Adrenal Gland Neuroblastoma — screening already-approved drugs against its 48-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
No approved-drug candidate for adrenal gland neuroblastoma is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
KRas proto-oncogene, GTPase (KRAS) — KRAS is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
RCSB Protein Data Bank · entry 7VVB · 1.7 Å · ligand PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER (GNP). Experimental structure, not a prediction.
Extra-adrenal neuroblastoma is described in a 1961 surgical series, but no patient numbers or survival data are given in that abstract. A 2008 case report notes that spontaneous bleeding within an adrenal neuroblastoma is known but that acute massive haemorrhage is exceptional; the report describes one infant presenting with life-threatening abdominal haemorrhage and shock. A 2007 report of bilateral adrenal neuroblastoma states that the disease rarely arises synchronously in both glands and that most such cases occur in children under one year; it presents one eight-year-old with stage IV disease, calling it the first report of bilateral disease in a child older than one year.
A 1996 review states that the mainstay of treatment for adrenal tumours is surgical removal, the only curative modality, but mentions advances in adjuvant therapies, typified by neoadjuvant use of 131I-methyl iodobenzylguanidine in neuroblastoma. A 2021 retrospective analysis of five patients aged 0 to 13 months with adrenal neuroblastoma is described, but the abstract gives no response rates, survival figures, or outcomes. A 2018 case report of a 14-year-old girl who developed brain metastases after neuroblastoma mass resection says she received multi-agent chemotherapy and her condition improved, and the authors conclude that chemotherapy may provide good prognosis, but the abstract provides no objective measures such as tumour shrinkage or survival time.
What is still missing are prospective trials with clearly defined endpoints, adequate sample sizes, and long-term follow-up. The available evidence consists of small case series and single case reports, none of which provide reliable response rates or survival data. No randomised comparisons exist. Patient stratification by age, stage, and molecular markers is absent from these abstracts, and no funding for a dedicated trial is mentioned.
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
AbstractExtra-adrenal neuroblastoma Get access H F Hope-Stone H F Hope-Stone Senior Registrar Radiotherapy Department, The London Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 48, Issue 210, January 1961, Pages 424–429, https://doi.org/10.1002/bjs.18004821013 Published: 06 December 2005
https://doi.org/10.1002/bjs.18004821013AbstractAdrenal hemorrhage after the neonatal period is rare. It most often occurs with coagulation disorders or child abuse. Spontaneous bleeding within an adrenal neuroblastoma has been described, but acute massive hemorrhage is exceptional. We describe a case of neuroblastoma of the adrenal gland presenting with acute life-threatening abdominal hemorrhage.
https://doi.org/10.1097/pec.0b013e31815f3c60AbstractTumors of the adrenal gland are not uncommon. Patients with these tumors usually demonstrate symptoms associated with the biochemical substance or hormone produced by the tumor. Tumors of the adrenal cortex, whether benign or malignant, are often associated with excess production of steroids, whereas tumors of the medulla are generally associated with overproduction of catecholamines. With the ubiquitous use of computed tomographic imaging, many asymptomatic adrenal lesions are discovered, presenting a management problem for the clinician. The algorithm for investigating so-called adrenal "incidentalomas" in the current era of cost containment continues to evolve. This review addresses current trends in the clinical evaluation, biochemical testing, and nuclear and radiologic imaging in the diagnostic work-up of these neoplasms. The mainstay of treatment is still surgical extirpation, the only curative modality. However, advances have occurred in adjuvant therapies, perhaps best typified by the neoadjuvant use of 131I-methyl iodobenzylguanidine in the treatment of neuroblastoma.
https://doi.org/10.1097/00001622-199601000-00006AbstractNeuroblastoma frequently arises from the adrenal gland and has rarely been reported to arise synchronously in both adrenal glands. The majority of reports of bilateral adrenal neuroblastoma are in children under the age of 1 year. We present a case of bilateral adrenal neuroblastoma in an 8-year-old child. This is the first report of bilateral disease in a child over the age of 1 year with stage IV neuroblastoma.
https://doi.org/10.1097/mph.0b013e318142b788AbstractAdrenal gland neuroblastoma in children The study includes a complex retrospective, analysis of medical records, clinical, imaging, morphopathological, laboratory observations and the results of surgical treatment of a series of patients from 0 and 13 months respectively with the diagnosis of Neuroblastoma of the adrenal gland, investigated and treated in „Natalia Gheorghiu” National Scientific and Practical Center for Pediatric Surgery of the Mother and Child Institute. Clinical and paraclinical data are elucidated consecutively in 5 patients and then they are compared with a case published by NCI (National Cancer Institute).
https://doi.org/10.52692/1857-0011.2021.2-70.03AbstractAim of the work: neuroblastoma of the adrenal gland is an extremely rare tumor in adulthood although it is one of the most common malignancies in childhood. Patient and method: a case of 14-year-old Saudi girl developed brain metastases after neuroblastoma mass resection. Results: the patient received Multi-agent chemotherapy and the condition of patient was improved. Conclusion: chemotherapy may provide good prognosis in treating neuroblastoma.
https://doi.org/10.12816/0044554Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
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