DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for adjustment disorder — screening already-approved drugs against its 4-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleAdjustment disorder maps to a 4-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for adjustment disorder is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
What the evidence adds up to
Adjustment disorder is a common diagnosis in clinical and liaison psychiatry populations, but research has been hindered by a lack of clear diagnostic criteria. The diagnostic criteria have historically been vague and not helpful in clinical practice, and relatively little research has been done on the disorder. The 2013 review notes that adjustment disorder carries a significant rate of morbidity, and that the diagnosis itself is controversial, with issues of differential and comorbid diagnosis highlighted. The 2006 paper states that adjustment disorder has received little scientific attention, with the focus instead on major depression, and that the two conditions have likely been conflated, which has crucial therapeutic and financial implications.
The 2019 paper reports that with the greater diagnostic clarity provided in DSM-5 and ICD-11, adjustment disorder has been increasingly recognised as an area of research interest. That paper evaluates the commonalities and differences between the ICD-11 and DSM-5 concepts, and reviews the current state of knowledge regarding its symptom profile, course, assessment, and treatment. No concrete numbers on survival, response rates, or sample sizes are provided in any of these abstracts, because none of them report a clinical trial or an intervention.
No drug is mentioned in any of these three abstracts. The papers are reviews of diagnostic status and future directions, not treatment studies. What is still missing is any controlled trial data for pharmacological or psychological interventions specifically for adjustment disorder, as well as clear patient stratification that separates adjustment disorder from major depression in research. Funding for such trials and a settled diagnostic framework that researchers and clinicians can reliably use remain absent.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
International Journal of Environmental Research and Public Health · 2019 · 125 citations · open access
Adjustment Disorder: Current Developments and Future Directions
AbstractDespite its high prevalence in clinical and consultant liaison psychiatry populations, adjustment disorder research has traditionally been hindered by its lack of clear diagnostic criteria. However, with the greater diagnostic clarity provided in the Diagnostic and Statistical Manual of Mental Disorders - fifth edition (DSM-5) and the International Statistical Classification of Diseases and Related Health Problems, 11th edition (ICD-11), adjustment disorder has been increasingly recognised as an area of research interest. This paper evaluates the commonalities and differences between the ICD-11 and DSM-5 concepts of adjustment disorder and reviews the current state of knowledge regarding its symptom profile, course, assessment, and treatment. In doing so, it identifies the gaps in our understanding of adjustment disorder and discusses future directions for research.
Indian Journal of Psychological Medicine · 2013 · 49 citations · open access
Adjustment Disorder: Current Diagnostic Status
AbstractAdjustment disorder is a common diagnosis in psychiatric settings and carries a significant rate of morbidity. However, diagnostic criteria are vague and not much helpful in clinical practice. Also there has been relatively little research done on this disorder. In this article, we review the information that is available on the epidemiology, clinical features, validity, and current diagnostic status of adjustment disorder. In this article, the controversy surrounding the diagnosis is also highlighted. It also discusses the differential and comorbid diagnosis. The various recommendations for DSM-V and ICD-11 conclude the article.
Expert Review of Neurotherapeutics · 2006 · 14 citations
The ‘afterthought’ diagnosis: rehabilitating adjustment disorders
AbstractAlthough a common diagnosis, adjustment disorder has received little scientific attention, and instead the focus has been on major depression. It is likely that adjustment disorder and major depression have been conflated and the reasons for this are explored. Delineating one from the other clearly has crucial therapeutic and financial implications.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
