DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for Adie syndrome — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
Disease moduleAdie syndrome maps to a 1-gene Open Targets module — the target space DeCure's AI scientist screens approved drugs against.
DeCure.ai methodSignature reversal (LINCS) plus network proximity (STRING) rank already-approved drugs likely to perturb this module — the same engine that produces DeCure.ai's repurposing hypotheses.
Repurposing thesisScreening approved medicines against this disease module, then publishing the evidence for the strongest candidate. Known pharmacology and human exposure data make the first question sharper — they do not establish safety or efficacy in a new indication.
Research record
01
ResearchComing soon
Candidate research + dossier — target rationale, drug-repurposing thesis and evidence pack.proof: Published dossier + on-chain hash
02
ValidationComing soon
In-vitro biological validation at a contract research org (CRO).proof: CRO contract + in-vitro report
03
Peer review & paperComing soon
Peer-reviewed paper published open-access (preprint + journal).proof: DOI + open-access link + on-chain hash
Current lead
No approved-drug candidate for adie syndrome is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
Molecular view
myelin protein zero (MPZ) — MPZ is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
Loading structure…
helix sheet apo structuredrag to rotate · scroll to zoom
RCSB Protein Data Bank · entry 8IIA · 2.09 Å · ligand none (apo structure). Experimental structure, not a prediction.
Evidence
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
Archives of Ophthalmology · 1943 · 0 citations
ADIE'S SYNDROME
Abstract<h3>To the Editor:</h3> —Dr. Rooks's article "Adie's Syndrome," in the June issue (Arch. Ophth.<b>29:</b>936, 1943) suggests that all cases of this syndrome "be brought to the attention of the medical profession with as much publicity as possible." I am in complete agreement with this idea, and I assume that if this is the purpose of the report, the cases which are described should be typical of the syndrome; should not be unusual and misleading varieties; should be carefully, completely and fully worked up, and should leave no doubt in the reader's mind as to just what the Adie syndrome is. I am aware that in conclusion the author states : . . . these 2 cases are offered for their clinical and scientific importance, with the hope that further interest in the study of Adie's syndrome may be stimulated, but my limited knowledge of the fundamental nature of this disorder warrants no
CHILDREN INFECTIONS · 2018 · 0 citations · open access
ADIE SYNDROME AS A COMPLICATION OF CHICKENPOX
AbstractAdie syndrome is a rare complication of chickenpox, which is seen in female mainly up to 6 years of age, one week after vesicular rash appearance. Aim: to introduce a case report of Adie syndrome as a complication of chickenpox. Material and methods: a case report of 8 years old female is introduced, who was hospitalized in Infectious Diseases Department — Varna, because of chickenpox. Anisocoria was diagnosed while the disease. We used epidemiologic and documental methods. Analyzes was made in the relevant departments of the St. Marina Hospital. The international literature data associated with the problem was studied. Results: we describe a patient with chickenpox. On the 9th day of the disease, Adie syndrome was diagnosed on the base of next symptoms: left mydriasis, accommodation paralysis, absent light reaction. Conclusion: Adie syndrome is a rare complication of chickenpox, with self-limitation tendency in the period of a year, but when early diagnosis is made together with specific treatment, normalization of eye functions occurs earlier.
Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
