Rare & Orphan Lab · DeCure for X
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for acute cor pulmonale — screening already-approved drugs against its 2-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
No approved-drug candidate for acute cor pulmonale is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
protein C, inactivator of coagulation factors Va and VIIIa (PROC) — PROC is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
RCSB Protein Data Bank · entry 1AUT · 2.8 Å · ligand D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide (0G6). Experimental structure, not a prediction.
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
AbstractCor pulmonale is a specific cardiovascular disorder secondary to chronic pulmonary disease in which there is hypoxemia, chronic carbon dioxide retention, polycythemia and right ventricular hypertrophy and failure. Aids to diagnosis are x-rays of the thorax, electrocardiograms, pulmonary function tests, and Astrup determinations. Data are presented on 52 patients with cor pulmonale.
https://doi.org/10.1080/00325481.1966.11696058AbstractCor pulmonale results from pathology of the lungs or their vessels; it does not include left ventricular (LV) failure, congenital heart defects (eg, ventricular septal defect), or secondary right ventricular (RV) dilatation due to acquired valvular pathology. Cor pulmonale is usually a chronic condition, but it can be acute and reversible. Primary pulmonary hypertension (i.e., not caused by lung or heart disease) is discussed elsewhere.
https://doi.org/10.5281/zenodo.14866770Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
