Rare & Orphan Lab · DeCure for X
DeCure's autonomous Rare AI scientist is researching a drug-repurposing hypothesis for acroosteolysis dominant type — screening already-approved drugs against its 1-gene Open Targets disease module to publish open-access research. Research is fast; the path to publication is funded in milestone stages.
No approved-drug candidate for acroosteolysis dominant type is corroborated in the literature DeepSearch retrieved. Some conditions are managed with non-pharmacological care — a device, surgery or physical therapy — rather than a medicine; that may be the case here, or the literature we found may simply be too sparse yet to support a drug-repurposing angle.
notch receptor 2 (NOTCH2) — NOTCH2 is one of the genes genetically linked to this disease in Open Targets — shown as context, not as a drug target we're pursuing: no approved-drug candidate for this disease is yet corroborated in the literature we found.
RCSB Protein Data Bank · entry 5MWB · 1.86 Å · ligand beta-D-glucopyranose (BGC). Experimental structure, not a prediction.
Retrieved by DeepSearch across 234,678,978 indexed works and resolved on OpenAlex — ranked by citations, including the results that did not work.
AbstractA patient with idiopathic acroosteolysis had unique papular skin lesions. To our knowledge, similar lesions have been previously mentioned only in connection with acroosteolysis seen in vinyl chloride processing, and a detailed description of these has not been noted in the literature.
https://doi.org/10.1001/archderm.1972.01620110056013AbstractDancers frequently present to the sports medicine clinic with a variety of lower extremity complaints ranging from acute and traumatic injuries to more chronic, overuse injuries. This case series depicts a similar and unique incidental radiographic finding found in 2 young dancers seen at the same sports medicine clinic. While the findings are likely benign and unrelated to both patients' initial presentation, the finding of acroosteolysis can be found in more serious systemic and genetic processes as well an early finding in repetitive trauma.
https://doi.org/10.1177/1941738115578604AbstractA patient with idiopathic acroosteolysis had unique papular skin lesions. To our knowledge, similar lesions have been previously mentioned only in connection with acroosteolysis seen in vinyl chloride processing, and a detailed description of these has not been noted in the literature.
https://doi.org/10.1001/archderm.106.2.224AbstractThe clinical phenomena of "acroosteolysis" means progredient destruction starting at metatarsal bony structures on primarily neurodystrophic mechanisms. A long-term case report illustrates clinical features and actual possibilities and limits in treatment. The current conceptions since the classic descriptions are resumed by large overview of literature. Open questions in current genetic and structural hypothesis show the difficulties of any nosologic classification. Common features with other neurodegenerative syndromes are more and more evident.
https://doi.org/10.1055/s-2008-1044507Disease module: DeepOracle (Open Targets). Structures: RDKit from PubChem SMILES. Literature: retrieved by DeepSearch across 234,678,978 indexed works (targeted per-candidate search), resolved on OpenAlex.
DeCure is a research and publication project, not medical advice and not a treatment. "DeCure for X" describes a research goal, not a claim that a cure exists. Backing a cure is a contribution to fund the research — it is not an investment, and confers no yield, royalty, equity or IP ownership. Papers are published open-access by the DeCure.ai DAO.
